Article first published online: 25 OCT 2007
Volume 20, Issue 4, pages 229–238, July 2007
How to Cite
Zwerner, J. and Fiorentino, D. (2007), Mycophenolate mofetil. Dermatologic Therapy, 20: 229–238. doi: 10.1111/j.1529-8019.2007.00136.x
- Issue published online: 25 OCT 2007
- Article first published online: 25 OCT 2007
- mycophenolate mofetil
ABSTRACT: Mycophenolate mofetil (MMF) is a relatively new systemic immunosuppressive agent whose use is rapidly increasing within the field of dermatologic. Originally used in the 1970s for the treatment of psoriasis, MMF has demonstrated efficacy in multiple types of inflammatory skin diseases. Although the safety data within the dermatologic literature is sparse, MMF's extensive use within the field of organ transplantation has demonstrated a favorable safety profile. MMF's lack of hepatic or renal toxicity is a significant advantage over immunosuppressive medications currently used in dermatology and make MMF an attractive candidate for multidrug regimens. In this review the present authors discuss the pharmacology, mechanisms of action, side effects and current uses of MMF reported within the dermatologic literature. The present authors also provide practical information regarding the use of the MMF culled from the literature as well as from the present authors’ own clinical experience with the medication.