Etiology of cicatricial alopecias: a basic science point of view
Article first published online: 15 JUL 2008
© 2008 Wiley Periodicals, Inc.
Volume 21, Issue 4, pages 212–220, July/August 2008
How to Cite
McElwee, K. J. (2008), Etiology of cicatricial alopecias: a basic science point of view. Dermatologic Therapy, 21: 212–220. doi: 10.1111/j.1529-8019.2008.00202.x
- Issue published online: 15 JUL 2008
- Article first published online: 15 JUL 2008
- cicatricial alopecia;
ABSTRACT: This article presents a short summary of our current knowledge of cicatricial alopecia disease pathogenesis and the hypothetical disease mechanisms that may be involved in scarring alopecia development. Several forms of scarring alopecia likely involve targeted cytotoxic action against hair follicle cells mediated by a folliculocentric inflammation. However, the specific nature of the inflammatory interference in hair follicle growth is open to question. A popular hypothesis of lymphocyte-mediated scarring alopecia development involves autoimmune targeting of hair follicle–specific self-antigens, although there is no direct evidence in support of such a view. Alternative hypotheses focus on defects in sebaceous gland function, destruction of hair follicle stem cells, and interference in the communication between hair follicle mesenchyme and epithelium. Many questions arise from these hypotheses, and addressing them with a systematic research approach may enable significant advances in understanding cicatricial alopecia etiology.