Vitamin D and innate immunity
Article first published online: 21 JAN 2010
© 2010 Wiley Periodicals, Inc.
Volume 23, Issue 1, pages 13–22, January/February 2010
How to Cite
Miller, J. and Gallo, R. L. (2010), Vitamin D and innate immunity. Dermatologic Therapy, 23: 13–22. doi: 10.1111/j.1529-8019.2009.01287.x
- Issue published online: 21 JAN 2010
- Article first published online: 21 JAN 2010
- UV exposure;
- vitamin D
Vitamin D's role in bone health has been well established. Recently, studies have identified additional roles of vitamin D in the immune system, cardiovascular system, and cancer prevention. The effect of vitamin D on the immune system is particularly relevant to the dermatologist in that it has implications for atopic dermatitis, psoriasis, and skin cancer. However, there is much disagreement on a dose of vitamin D that is both safe and effective as both ultraviolet exposure and certain vitamin D-rich foods come with unwanted consequences. This review aims to update the dermatologist on the roles of vitamin D in the immune system, the safety and dose of different sources, and risk factors for vitamin D deficiency that may necessitate supplementation. Immune consequences of vitamin D status represent one additional aspect that illustrates how guidelines for supplementation are needed and will only be useful clinically if they are presented in context with validated controlled clinical trials.