Conflict of interest: none.
Paraneoplastic vasculitis and paraneoplastic vascular syndromes
Article first published online: 3 NOV 2010
© 2010 Wiley Periodicals, Inc.
Volume 23, Issue 6, pages 597–605, November/December 2010
How to Cite
Buggiani, G., Krysenka, A., Grazzini, M., Vašků, V., Hercogová, J. and Lotti, T. (2010), Paraneoplastic vasculitis and paraneoplastic vascular syndromes. Dermatologic Therapy, 23: 597–605. doi: 10.1111/j.1529-8019.2010.01367.x
- Issue published online: 3 NOV 2010
- Article first published online: 3 NOV 2010
Paraneoplastic syndromes are localized or diffuse pathologic manifestations that may occur in subjects affected by neoplastic diseases, even occult ones.
Among the many clinical manifestations of paraneoplastic syndromes, cutaneous ones are quite common. It is estimated that skin manifestations may represent the very first diagnostic sign of a neoplastic disease in about 1% of patients.
Many paraneoplastic syndromes with skin manifestations are caused by vascular alterations. In case of solid tumors, migrant thrombophlebitis and blood hypercoagulability can be seen, whereas in case of hematological neoplasms, vasculitis, and erythromelalgia can occur.
Paraneoplastic vasculitis and paraneoplastic vascular syndromes are challenging issues in dermatology and general medicine. The present article will review the actual knowledge in the argument, together with providing hints for its diagnosis and management.