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Approach to the patient with autoimmune mucocutaneous blistering diseases

Authors


Naveed Sami, MD, FAAD, Assistant Professor Dermatology, University of Alabama Birmingham, 1720 University Blvd, EFH 414, Birmingham, AL 35294, or email: nsblister@yahoo.com.

ABSTRACT

Autoimmune mucocutaneous blistering diseases (AMBD) are a rare group of dermatoses that can be potentially fatal. There are many subtypes and their clinical presentation can vary from being localized to general involvement. It is crucial that a diagnosis be made as early as possible and appropriate treatments are implemented. This article will discuss the diagnosis and available treatments of the major AMBDs. There are very few case-controlled studies regarding the treatments of these diseases. Most of the treatments used for these diseases are based on anecdotal reports. Hence, a synopsis of the conventional treatments and some brief recommendations will also be discussed. A brief discussion regarding “rescue” therapies that have been used for those patients with more recalcitrant cases of AMBD will also be presented.

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