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Cutaneous graft-versus-host disease: rationales and treatment options


R.A. el-Azhary MD, PhD, Department of Dermatology, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, or email:


The treatment of cutaneous graft-versus-host disease (GVHD) is one of the most challenging clinical scenarios in a dermatological practice. Given the significant risk of morbidity and mortality in this patient group, it is important for a dermatologist to understand the pathophysiology of GVHD, as well as their role within a multidisciplinary practice where many immunosuppressants are prescribed. A significant proportion of the patients with GVHD will require a combination treatment regimen in order to stem the progression of their disease. In this review, the stages, type of GVHD and treatment options are reviewed for the dermatologist.