Cytotoxic agents represent the oldest class of chemotherapy drugs. These agents interrupt the replication of rapidly dividing malignant and nonmalignant cells by interfering with DNA replication. Resultant toxicity commonly affects the bone marrow, skin, and intestinal epithelium. In addition, there exist specific dermatologic reaction patterns that may appear. The present review highlights the most common specific and nonspecific dermatologic adverse effects seen with cytotoxic chemotherapeutic agents.