Genetic counseling in melanoma

Authors

  • Celia Badenas,

    Corresponding author
    1. Biochemical and Molecular Genetics Service
    • Centro Investigación Biomédica en Red en Enfermedades Raras (CIBERER)
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  • Paula Aguilera,

    1. Centro Investigación Biomédica en Red en Enfermedades Raras (CIBERER)
    2. Dermatology Department, Melanoma Unit, Hospital Clinic & IDIBAPS (Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer), Barcelona, Spain
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  • Joan A. Puig-Butillé,

    1. Centro Investigación Biomédica en Red en Enfermedades Raras (CIBERER)
    2. Biochemical and Molecular Genetics Service
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  • Cristina Carrera,

    1. Centro Investigación Biomédica en Red en Enfermedades Raras (CIBERER)
    2. Dermatology Department, Melanoma Unit, Hospital Clinic & IDIBAPS (Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer), Barcelona, Spain
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  • Josep Malvehy,

    1. Centro Investigación Biomédica en Red en Enfermedades Raras (CIBERER)
    2. Dermatology Department, Melanoma Unit, Hospital Clinic & IDIBAPS (Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer), Barcelona, Spain
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  • Susana Puig

    1. Centro Investigación Biomédica en Red en Enfermedades Raras (CIBERER)
    2. Dermatology Department, Melanoma Unit, Hospital Clinic & IDIBAPS (Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer), Barcelona, Spain
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  • Funding/Support: The research at the Melanoma Unit in Barcelona is partially funded by Grants 03/0019, 05/0302, 06/0265, and 09/1393 from Fondo de Investigaciones Sanitarias, Spain; by the CIBER de Enfermedades Raras of the Instituto de Salud Carlos III, Spain; by the AGAUR 2009 SGR 1337 of the Catalan Government, Spain; by the European Commission under the 6th Framework Programme, Contract No: LSHC-CT-2006-018702 (GenoMEL); and by the National Cancer Institute (NCI) of the US National Institute of Health (NIH) (CA83115).
  • Role of the Sponsors: The sponsors had no role in the design and conduct of the study; in the collection, analysis, and interpretation of data; or in the preparation, review, or approval of the manuscript.

Address correspondence and reprint requests to: Celia Badenas, PhD, Biochemical and Molecular Genetics Service, Melanoma Unit, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain, or email: cbadenas@clinic.ub.es.

Abstract

Genetic counseling may be offered to families with melanoma and to individuals with multiple melanomas to better understand the genetic susceptibility of the disease, the influence of environmental factors, the inheritance of the risk, and behavior that decreases the risk of dying from melanoma, including specific dermatological follow-up such as total body photography and digital dermoscopy. Genetic testing may be offered to those individuals with more than a 10% chance of being a carrier of a mutation. This risk varies according to the incidence of melanoma in the country and sun behavior. In countries with a low-medium incidence of melanoma, genetic testing should be offered to families with two cases of melanoma or an individual with two primary melanomas. In countries with a high incidence, families with three cases of melanoma, with two melanomas and one pancreatic adenocarcinoma, or patients with three primary melanomas, may benefit from genetic testing.

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