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Non-length dependent small fiber neuropathy. A prospective case series


Dr. Franco Gemignani, Dipartimento di Neuroscienze, Università di Parma, via Gramsci 14, I-43100, Parma, Italy. Tel: +39 0521 704118; Fax: +39 521 704115; E-mail:


We report the features of non-length dependent small fiber neuropathy (SFN) and compare them to those with distal length-dependent SFN. In a series of 224 consecutive neuropathy patients, we evaluated 44 patients with SFN diagnosed in the presence of both symptoms and signs. Eleven were classified as non-length dependent SFN. Disease associations were Sjögren's syndrome (two patients), impaired glucose tolerance, rheumatoid arthritis, hepatitis C virus, Crohn's disease, and idiopathic (five patients). In the 33 patients with distal SFN, the age of onset was significantly older and more had impaired glucose metabolism (16/33). In both groups, pain was mainly characterized as burning, but patients with non-length dependent SFN more often reported an “itchy” quality and allodynia to light touch.