This research was supported in part by a Research Scientist Development Award (AA00077) and a grant (AA06902) from the National Institute on Alcohol Abuse and Alcoholism to EPR.
Alterations in Gait Following Ethanol Exposure During the Brain Growth Spurt in Rats
Article first published online: 11 APR 2006
Alcoholism: Clinical and Experimental Research
Volume 14, Issue 1, pages 23–27, February 1990
How to Cite
Meyer, L. S., Kotch, L. E. and Riley, E. P. (1990), Alterations in Gait Following Ethanol Exposure During the Brain Growth Spurt in Rats. Alcoholism: Clinical and Experimental Research, 14: 23–27. doi: 10.1111/j.1530-0277.1990.tb00440.x
- Issue published online: 11 APR 2006
- Article first published online: 11 APR 2006
- Received for publication April 13, 1989; revised manuscript received July 31, 1989; accepted August 21, 1989.
Walking patterns were assessed in rats that had been exposed to alcohol neonatally during a period encompassing the brain growth spurt. Rat pups were exposed via an artificial rearing technique to either a 2.50% (w/v) or 2.15% (w/v) EtOH-milk formula on Days 26-32 postconception. An artificially reared control group and a suckle-control group were also included in the experiment. Gait patterns were assessed in animals from each of the neonatal treatment groups at 43, 67, and 87 days postconception. No differences in gait patterns were evident on Day 43 postconception; however, on Days 67 and 87 animals exposed to alcohol during the neonatal period displayed an abnormal gait. These animals had a shortened stride length and an increased angle of placement of the hindfeet relative to artificially reared and suckle-control animals. The altered gait pattern may be the result of alcohol-induced hippocampal and cerebellar damage during the brain growth spurt.