This research was supported by National Institute on Alcohol Abuse and Alcoholism Grant No. AA06433 to the first author.
Vagal Mediation of the Effect of Alcohol on Heart Rate
Article first published online: 11 APR 2006
Alcoholism: Clinical and Experimental Research
Volume 14, Issue 3, pages 421–424, June 1990
How to Cite
Newlin, D. B., Byrne, E. A. and Porges, S. W. (1990), Vagal Mediation of the Effect of Alcohol on Heart Rate. Alcoholism: Clinical and Experimental Research, 14: 421–424. doi: 10.1111/j.1530-0277.1990.tb00498.x
- Issue published online: 11 APR 2006
- Article first published online: 11 APR 2006
- Received for publication November 9, 1989; revised manuscript received January 25, 1990; accepted January 29, 1990
Alcohol (0.5 g/kg bodyweight) was administered in two sessions and placebo in a third session to normal, healthy social drinkers. A control group was administered a mixer (i.e., no alcohol) for each of the three sessions. The heart rate and vagal tone index (V) response patterns were different to alcohol than to the mixer or placebo. The treatments did not differentially influence pulse transit time. The results indicated that the acute effect of a moderate dose of alcohol on the heart is parasympathetically (i.e., vagally) mediated and has no significant direct sympathetic component.