This work was supported by National Institute on Alcohol Abuse and Alcoholism (AA-05965) and the Department of Veterans Affairs.
Event-Related Potentials in Alcoholic Men: P3 Amplitude Reflects Family History But Not Alcohol Consumption
Article first published online: 11 APR 2006
Alcoholism: Clinical and Experimental Research
Volume 15, Issue 5, pages 839–850, October 1991
How to Cite
Pfefferbaum, A., Ford, J. M., White, P. M. and Mathalon, D. (1991), Event-Related Potentials in Alcoholic Men: P3 Amplitude Reflects Family History But Not Alcohol Consumption. Alcoholism: Clinical and Experimental Research, 15: 839–850. doi: 10.1111/j.1530-0277.1991.tb00611.x
- Issue published online: 11 APR 2006
- Article first published online: 11 APR 2006
- Received for publication November 5, 1990; accepted April 11, 1991
- Event-Related Potentials;
- Sartle Blinks;
- Family History;
- Alcohol Consumption
Multilead event-related potentials (ERPs), elicited by auditory and visual stimuli requiring a button press response and by a startling noise requiring no response, were recorded from male alcoholics and age-matched male controls (26–60 years old). Single-trial analyses of blink responses to the startling stimuli indicated that alcoholics startle less frequently but with equivalent amplitude as the controls. In contrast, single-trial analyses of P3 indicated that alcoholics generate a P3 as often as controls, but that their individual P3s are smaller. Alcoholics who reported a positive family history of problem drinking had larger startle blink amplitudes and smaller auditory and visual P3s than did alcoholics who reported a negative family history. Hierarchical regression analysis was used to demonstrate that smaller P3s in family history positive alcoholics were independent of lifetime alcohol consumption.