Selective Breeding of Rats Differing in Sensitivity to the Effects of Acute Ethanol Administration

Authors

  • Laura J. Draski,

    Corresponding author
    1. Department of Pharmacology, and School of Pharmacy (V.G.E.), Alcohol Research Center, University of Colorado Health Sciences Center, Denver, Colorado.
    Search for more papers by this author
  • Karen P. Spuhler,

    1. Department of Pharmacology, and School of Pharmacy (V.G.E.), Alcohol Research Center, University of Colorado Health Sciences Center, Denver, Colorado.
    Search for more papers by this author
  • V. Gene Erwin,

    1. Department of Pharmacology, and School of Pharmacy (V.G.E.), Alcohol Research Center, University of Colorado Health Sciences Center, Denver, Colorado.
    Search for more papers by this author
  • Rodney C. Baker,

    1. Department of Pharmacology, and School of Pharmacy (V.G.E.), Alcohol Research Center, University of Colorado Health Sciences Center, Denver, Colorado.
    Search for more papers by this author
  • Richard A. Deitrich

    1. Department of Pharmacology, and School of Pharmacy (V.G.E.), Alcohol Research Center, University of Colorado Health Sciences Center, Denver, Colorado.
    Search for more papers by this author

  • This work was supported by grants R01AA-05868 and K05-AA-00093 from NIAAA (R.A.D.).

  • A preliminary report has appeared.46

Reprint requests: Laura J. Draski, Department of Pharmacology, Alcohol Research Center, University of Colorado Health Sciences Center, Denver, CO 80262.

Abstract

Selective breeding of rats for sensitivity to the anesthetic effects of ethanol is being carried out with rats derived from the genetically heterogeneous N/Nih stock. Thirteen generations of within family selection have been achieved with replicate high (HAS), low (LAS) and control alcohol sensitive (CAS) lines. Significant separation between lines on sleep time and blood ethanol concentration (BEC) at awakening following ethanol administration has been achieved. In general, the results obtained so far replicate the findings with short (SS) and long (LS) sleep mice. One exception is that the high alcohol sensitivity rats (HAS) also appear more sensitive to pentobarbital relative to LAS rats. This finding is opposite to that which occurs with SS and LS mice where the low ethanol sensitive SS mice appear more sensitive to pentobarbital than the LS mice.

Ancillary