This work was supported by grants R01AA-05868 and K05-AA-00093 from NIAAA (R.A.D.).
Selective Breeding of Rats Differing in Sensitivity to the Effects of Acute Ethanol Administration
Article first published online: 11 APR 2006
Alcoholism: Clinical and Experimental Research
Volume 16, Issue 1, pages 48–54, January 1992
How to Cite
Draski, L. J., Spuhler, K. P., Erwin, V. G., Baker, R. C. and Deitrich, R. A. (1992), Selective Breeding of Rats Differing in Sensitivity to the Effects of Acute Ethanol Administration. Alcoholism: Clinical and Experimental Research, 16: 48–54. doi: 10.1111/j.1530-0277.1992.tb00634.x
A preliminary report has appeared.46
- Issue published online: 11 APR 2006
- Article first published online: 11 APR 2006
- Received for publication March 29, 1991; accepted September 16, 1991
- High Alcohol Sensitivity;
- Low Alcohol Sensitivity;
- Selective Breeding;
Selective breeding of rats for sensitivity to the anesthetic effects of ethanol is being carried out with rats derived from the genetically heterogeneous N/Nih stock. Thirteen generations of within family selection have been achieved with replicate high (HAS), low (LAS) and control alcohol sensitive (CAS) lines. Significant separation between lines on sleep time and blood ethanol concentration (BEC) at awakening following ethanol administration has been achieved. In general, the results obtained so far replicate the findings with short (SS) and long (LS) sleep mice. One exception is that the high alcohol sensitivity rats (HAS) also appear more sensitive to pentobarbital relative to LAS rats. This finding is opposite to that which occurs with SS and LS mice where the low ethanol sensitive SS mice appear more sensitive to pentobarbital than the LS mice.