This study was supported by a postgraduate research scholarship from the National Health and Medical Research Council of Australia. This work was performed at the Westmead Hospital, Westmead, New South Wales, Australia 2145.
Dietary Carbohydrate Accelerates Ethanol Elimination, But Does Not Alter Hepatic Alcohol Dehydrogenase
Version of Record online: 11 APR 2006
Alcoholism: Clinical and Experimental Research
Volume 17, Issue 2, pages 431–433, April 1993
How to Cite
Keegan, A. and Batey, R. (1993), Dietary Carbohydrate Accelerates Ethanol Elimination, But Does Not Alter Hepatic Alcohol Dehydrogenase. Alcoholism: Clinical and Experimental Research, 17: 431–433. doi: 10.1111/j.1530-0277.1993.tb00789.x
- Issue online: 11 APR 2006
- Version of Record online: 11 APR 2006
- Received for publication September 8, 1992; accepted November 9, 1992
- Ethanol Elimination
In naive animals the rate of ethanol elimination is dependent on the hepatic alcohol dehydrogenase activity. Carbohydrates have been shown to modify ethanol metabolism by a mechanism that has not been determined. In this study, adult female rats, fed chow diets supplemented with fructose or glucose in their drinking water for 10 days demonstrated significantly greater ethanol elimination rates (4.85 ± 0.28 and 4.92 ± 1.5 μm ethanol/min/g liver, respectively) than rats receiving water (3.65 ± 0.29). The hepatic alcohol dehydrogenase activity of the fructose (1687 ± 101 nm ethanol/min/g liver) and the glucose (1832 ± 15)-supplemented rats were not significantly different from that of control rats (1845 ± 160). Dietary carbohydrate supplementation, therefore, enhanced ethanol elimination, but did not alter the activity of alcohol dehydrogenase. Thus the changes in the ethanol elimination rate following carbohydrate loading were not the consequence of an alteration in hepatic alcohol dehydrogenase.