This work was supported by grants from the Department of Veterans Affairs, the National Institute of Alcohol Abuse and Alcoholism (AA08621), and the Alcoholic Beverage Medical Research Foundation.
Effects of Acute and Repeated Ethanol Exposures on the Locomotor Activity of BXD Recombinant Inbred Mice
Article first published online: 11 APR 2006
Alcoholism: Clinical and Experimental Research
Volume 19, Issue 2, pages 269–278, April 1995
How to Cite
Phillips, T. J., Huson, M., Gwiazdon, C., Burkhart-Kasch, S. and Shen, E. H. (1995), Effects of Acute and Repeated Ethanol Exposures on the Locomotor Activity of BXD Recombinant Inbred Mice. Alcoholism: Clinical and Experimental Research, 19: 269–278. doi: 10.1111/j.1530-0277.1995.tb01502.x
- Issue published online: 11 APR 2006
- Article first published online: 11 APR 2006
- Received for publication May 18, 1994; accepted September 15, 1994
- BXD Recombinant In-breds;
- Quantitative Trait Loci
Investigations of ethanol's (EtOH's) complex response profile, including locomotor and other effects, are likely to lead to a more in-depth understanding of the constituents of alcohol addiction. Locomotor activity responses to acute and repeated EtOH (2 g/kg, ip) exposures were measured in BXD recombinant inbred (RI) mice and their C57BL/6J (B6) and DBA/2J (D2) progenitors. Both the acute response and the change in initial EtOH response with repeated treatments were strain-dependent. The coefficient of genetic determination was 0.38–0.49 for initial locomotor response to EtOH, and 0.29 for change in response. Changes in response were largely attributable to sensitization of locomotor stimulation. Quantitative trait loci (QTL) analyses identified significant marker associations with basal activity, acute locomotor response, and change in response. Markers were for QTL on several chromosomes, and there was only one case of overlap in marker associations among phenotypes. Acute locomotor response and locomotor sensitization were negatively correlated with 3% EtOH preference drinking data collected in BXD Rl strains. Overall, these results demonstrate locomotor sensitization induced by EtOH, suggest independence of genetic determination of locomotor responses to acute and repeated EtOH exposure, and partially support a relationship between reduced sensitivity to the locomotor stimulant/sensitizing effects of EtOH and EtOH consumption.