This research was supported in part by the National Institute on Alcohol Abuse and Alcoholism Grants AA-08125 andAA-08454, and by the National Institute on Drug Abuse Grant DA-07171. LA.R. is supported in part by the National Institute on Drug Abuse Grant DA-07277–02.
Alcohol Acceptance, Preference, and Sensitivity in Mice. II. Quantitative Trait Loci Mapping Analysis Using BXD Recombinant Inbred Strains
Article first published online: 11 APR 2006
Alcoholism: Clinical and Experimental Research
Volume 19, Issue 2, pages 367–373, April 1995
How to Cite
Rodriguez, L. A., Plomin, R., Blizard, D. A., Jones, B. C. and McClearn, G. E. (1995), Alcohol Acceptance, Preference, and Sensitivity in Mice. II. Quantitative Trait Loci Mapping Analysis Using BXD Recombinant Inbred Strains. Alcoholism: Clinical and Experimental Research, 19: 367–373. doi: 10.1111/j.1530-0277.1995.tb01517.x
- Issue published online: 11 APR 2006
- Article first published online: 11 APR 2006
- Received for publication May 14, 1994; accepted October 11, 1994
- Alcohol Acceptance;
- Alcohol Preference;
- Hypnotic Dose Sensitivity;
- Recombinant Inbred Strains
Quantitative trait loci (QTL) mapping of complex phenotypes has emerged as an important feature of the recombinant inbred (Rl) strain methodology. In this second study of our series on alcohol-related behaviors in mice, we examine alcohol acceptance, preference, and hypnotic dose sensitivity (HDS) to a standard dose of alcohol measured in BXD RI strains to identify candidate QTL regions responsible for their heritability. We detected highly significant marker associations for acceptance on chromosome 12 (Eif4e), for preference on chromosome 1 (D1Rti2) and chromosome 7 (D7Mit7), and for HDS on chromosome 7 (Mpmv1). These are the strongest QTL associations that we detected, but several other candidate QTL regions are reported. Given the limited number of BXD RI strains available, the large number of markers used herein, and the consequent chance of identifying false marker associations, these RI QTL mapping results must be seen as tentative, but an important first step toward identifying QTL for alcohol-related behaviors.