This study was supported by grants AA 10980 to D.J. W. and AA 07565 to P.H.J, and by a Tourette Syndrome Association Award to P.H.J. Technological development was supported by NSF DBI 9110308 and 99619063, and ONR N 14-96-1-1104 to D.J.W.
Ethanol Action on Neural Networks Studied with Multineuron Recording in Freely Moving Animals
Version of Record online: 30 MAY 2006
Alcoholism: Clinical and Experimental Research
Volume 22, Issue 1, pages 10–22, February 1998
How to Cite
Woodward, D. J., Janak, P. H. and Chang, J.-Y. (1998), Ethanol Action on Neural Networks Studied with Multineuron Recording in Freely Moving Animals. Alcoholism: Clinical and Experimental Research, 22: 10–22. doi: 10.1111/j.1530-0277.1998.tb03612.x
- Issue online: 30 MAY 2006
- Version of Record online: 30 MAY 2006
- Recording Techniques;
The advent of new chronic multineuron recording techniques for examining neural activity in behaving animals has initiated a new phase in the analysis of the neuronal mechanisms that underlie ethanol and other drug self-administration. The technique allows for the simultaneous recording of groups of individual neurons in one or more brain regions during ongoing behavior; therefore, the spatiotemporal patterns of neuronal activity during specific behavioral events can be determined. We have successfully applied this technique to rat models of cocaine and heroin self-administration. Recently, using rats, we have been able to record from neurons in areas of the mesocorticolimbic circuit during ethanol-reinforced operant responding. In this review, we describe the current and future application of this new behavioral neurophysiology to the investigation of the neurobiology of alcohol addiction.