This research was supported by the National Institute on Alcohol Abuse and Alcoholism (R29 09484) and by the Alcohol Beverage Medical Research Foundation.
Cognitive Correlates of Single Neuron Activity in Task-Performing Animals: Application to Ethanol Research
Article first published online: 30 MAY 2006
Alcoholism: Clinical and Experimental Research
Volume 22, Issue 1, pages 23–31, February 1998
How to Cite
Givens, B., Williams, J. and Gill, T. M. (1998), Cognitive Correlates of Single Neuron Activity in Task-Performing Animals: Application to Ethanol Research. Alcoholism: Clinical and Experimental Research, 22: 23–31. doi: 10.1111/j.1530-0277.1998.tb03613.x
- Issue published online: 30 MAY 2006
- Article first published online: 30 MAY 2006
The deleterious effects of ethanol on cognitive processes result from an interaction between ethanol and the neural structures that are critical for executing those cognitive functions. Results from studies that employ contemporary behavioral neuroscience techniques are beginning to elucidate the neural circuits that underlie specific cognitive processes, and the stage is set for rigorous investigations into the neural basis for ethanol-induced cognitive impairments. In this article, the application of single neuron recording techniques to the study of the memory and attentional deficits produced by acute exposure to low levels of ethanol are described, with an emphasis on the advantages of combining physiological techniques with operant behavioral procedures in rats. After reviewing background information on the basic neurophysiological and behavioral techniques, empirical results from this laboratory will be used to illustrate how single-unit analysis can be applied to the study of ethanol-induced cognitive impairments.