This study was supported by the Spanish Ministry of Education and Culture (DGICYT) Grants PM91-0159-C02-02 and PB95-0856.
Visual and Auditory Event-Related Potentials in Young Children of Alcoholics from High- and Low-Density Families
Article first published online: 30 MAY 2006
Alcoholism: Clinical and Experimental Research
Volume 22, Issue 1, pages 87–96, February 1998
How to Cite
Holguín, S. R., Corral, M. and Cadaveira, F. (1998), Visual and Auditory Event-Related Potentials in Young Children of Alcoholics from High- and Low-Density Families. Alcoholism: Clinical and Experimental Research, 22: 87–96. doi: 10.1111/j.1530-0277.1998.tb03620.x
- Issue published online: 30 MAY 2006
- Article first published online: 30 MAY 2006
- Received for publication February 11, 1997; accepted September 23, 1997
- Children of Alcoholics;
- Event-Related Potentials;
- P3 (P300);
- Risk Markers
Event-related potentials (ERPs), particularly the P3 wave, have been proposed as biological markers of genetic risk for alcoholism. The present study assesses the ERPs from 102 boys and girls (7 to 15 years old) divided into three groups: two groups of sons and daughters of alcoholic fathers, with and without other first- or second-degree relatives affected, and a control group of children of nonal-coholics. Both visual and auditory discrimination tasks with three stimuli (standard, target, and infrequent nontarget) were used. P3 amplitudes did not reach significant reduction for the high-risk males and were complex for females. There were significant differences among females in P3 visual latency elicited by targets; delays in this variable were associated with multigenerational familial alcoholism. Results are discussed in light of the tasks used for eliciting the ERPs and the characteristics of the selected sample.