Prenatal Alcohol Exposure and Development at Preschool Age: Main Results of a French Study

Authors

  • Beatrice Larroque,

    Corresponding author
    1. Epidemiologic Research Unit on Women and Children's Health, INSERM (National Institute for Health and Medical Research), Villejuif, France.
    Search for more papers by this author
  • Monique Kaminski

    1. Epidemiologic Research Unit on Women and Children's Health, INSERM (National Institute for Health and Medical Research), Villejuif, France.
    Search for more papers by this author

  • Presented at the 1996 Borchard Foundation Symposium on the Behavioral Effects in Children following Prenatal Alcohol Exposure, Missillac, France, July 28–30, 1996.

  • This study was funded by the Haut Comitéď Etudes et ďInformation sur ľ Alcoolisme, the Foundation de France and INSERM. B.L. received a grant from SESEP (SociétéďEtude et de Soins sur les enfants Paralysés et Polymalformés).

Reprint requests: Beatrice Larroque, Ph.D., INSERM U149, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France.

Abstract

Very high levels of alcohol consumption during pregnancy are harmful for the central nervous system of the child and affect morphogenesis and growth. The aim of this study was to investigate the effects of moderate prenatal alcohol exposure on development at preschool age in a longitudinal study. Pregnant women were interviewed on their alcohol consumption during pregnancy at their first visit to the maternity hospital of Roubaix, France. The development of their 160 children was assessed at the age of 4½. Multiple regression analyses indicated that consumption of 1.5 oz of absolute alcohol (approximately 3 drinks) or more during pregnancy was significantly related to a decrease of 7 points on the general cognitive index of the McCarthy scales, after controlling for confounders. This level of consumption was also related to a higher score on minor neurological anomalies, a lower height of the child, and a higher score on facial features. This level of 1.5 oz of absolute alcohol/day should not be interpreted as a biological threshold, because the study does not allow conclusions to be drawn regarding the effects of lower levels of alcohol consumption. Alcohol consumption during pregnancy can affect the development of the child, at levels well below those associated with fetal alcohol syndrome.

Ancillary