Presented at the 1996 Borchard Foundation Symposium on the Behavioral Effects in Children following Prenatal Alcohol Exposure, Missillac, France, July 28–30, 1996.
Relation of Maternal Age and Pattern of Pregnancy Drinking to Functionally Significant Cognitive Deficit in Infancy
Article first published online: 30 MAY 2006
Alcoholism: Clinical and Experimental Research
Volume 22, Issue 2, pages 345–351, April 1998
How to Cite
Jacobson, J. L., Jacobson, S. W., Sokol, R. J. and Ager, J. W. (1998), Relation of Maternal Age and Pattern of Pregnancy Drinking to Functionally Significant Cognitive Deficit in Infancy. Alcoholism: Clinical and Experimental Research, 22: 345–351. doi: 10.1111/j.1530-0277.1998.tb03659.x
This study was supported by the National Institute on Alcohol Abuse and Alcoholism (Grants R01-AA06966, P50-AA07606, and R01-AA09524), with supplemental support from the National Institutes of Health Minority Biomedical Research Support Grant S06-RR08167.
- Issue published online: 30 MAY 2006
- Article first published online: 30 MAY 2006
- Fetal Alcohol Syndrome;
- Alcohol-Related Neurodevel-opmental Disorder;
- Prenatal Alcohol Exposure;
- Maternal Age
Prospective studies of the effects of prenatal alcohol exposure on development have focused primarily on the detection of subtle deficits. This study was designed to extend those findings by evaluating dose-response, functional significance, and pattern of drinking in greater detail. 480 African-American infants, recruited to overrepre-sent prenatal exposure at moderate-to-heavy levels, were assessed. For the five outcomes tested, nonparametric and hockey stick regression analyses both indicated essentially no relation between pregnancy drinking and developmental outcome below a median threshold of 0.5 oz absolute alcohol/day, with the impact of the exposure increasing gradually above threshold. Functional deficit was defined in terms of performance in the bottom 10th percentile of the distribution. For four of the five outcomes tested, there was no increased incidence of functionally significant deficit in infants born to moderate-to-heavy drinking mothers < 30 years old, whereas those born to older drinking mothers were 2 to 5 times more likely to be functionally impaired. Among the infants exposed above threshold, functionally significant deficits were seen primarily in those whose mothers averaged at least 5 drinks/occasion on an average of at least once/week. By contrast, a history of alcohol abuse was not related to functional deficit. These data suggest that efforts to reduce the incidence of alcohol-related functional impairment should specifically target the older mother who engages in intermittent heavy drinking during pregnancy.