This work was supported by U.S. Public Service Grants AA10722 (IRPG I). AA10707 (IRPG 2), and AA07611.
A Quantitative Trait Locus for Alcohol Consumption in Selectively Bred Rat Lines
Article first published online: 30 MAY 2006
Alcoholism: Clinical and Experimental Research
Volume 22, Issue 4, pages 884–887, June 1998
How to Cite
Carr, L. G., Foroud, T., Bice, P., Gobbett, T., Ivashina, J., Edenberg, H., Lumeng, L. and Li, T.-K. (1998), A Quantitative Trait Locus for Alcohol Consumption in Selectively Bred Rat Lines. Alcoholism: Clinical and Experimental Research, 22: 884–887. doi: 10.1111/j.1530-0277.1998.tb03883.x
- Issue published online: 30 MAY 2006
- Article first published online: 30 MAY 2006
- Received for publication November 21, 1997; accepted January 28, 1998
- Quantitative Trait Locus (QTL);
- Rat Lines;
- Chromosome 4;
- Neuropeptide Y
Selective breeding for high and low alcohol consumption led to the establishment of alcohol-preferring (P) and alcohol-nonpreferring (NP) rat lines that differ greatly in their alcohol consumption. These lines were inbred and F2 intercross progenies were generated to detect quantitative trait loci (QTLs) influencing alcohol consumption. A QTL on chromosome 4 was identified with a maximum lod score of 8.6. This QTL acts in an additive fashion and accounts for 11% of the total phenotypic variability and approximately one-third of the genetic variability. Neuropeptide Y, an endogenous anxiolytic and neu-romodulator, has been mapped to this same region of chromosome 4. This study is an advance in genome analyses, demonstrating that crosses between divergent, selectively bred rat lines can be used to identify QTLs. Localization of a gene influencing alcohol consumption may have important implications for the etiology of alcohol abuse and alcoholism in humans.