This study was supported by a grant from the Finnish Foundation for Alcohol Studies.
Dopamine Release During Ethanol Drinking in AA Rats
Article first published online: 30 MAY 2006
Alcoholism: Clinical and Experimental Research
Volume 22, Issue 8, pages 1628–1633, November 1998
How to Cite
Nurmi, M., Sinclair, J. D. and Kiianmaa, K. (1998), Dopamine Release During Ethanol Drinking in AA Rats. Alcoholism: Clinical and Experimental Research, 22: 1628–1633. doi: 10.1111/j.1530-0277.1998.tb03959.x
We thank Leena Tanner-Väisänen for her enthusiastic and skillful work.
- Issue published online: 30 MAY 2006
- Article first published online: 30 MAY 2006
- Received for publication May 27, 1997; accepted June 29, 1998
- AA Rats
The dopamine overflow in the nucleus accumbens of rats from the high alcohol drinking AA line was measured by microdialysis before, during, and after one-half hour sessions of cued drinking of ethanol flavored with saccharin and peppermint or, as a control, saccharinpeppermint drinking. The animals had had extensive previous experience with ethanol drinking. Self-administration of the ethanol solution did not raise the dopamine level substantially: there was a small (17%) but significant increase only during the first 10 min after the onset of drinking. Giving the rats a cue for ethanol, which was part of their daily routine drinking regime, did not raise the dopamine level before ethanol was presented to the rats (i.e., during “anticipation”). The results are consistent with our previous studies showing a lack of a large ethanol-induced dopamine response in rats with previous experience of drinking ethanol and with the idea that although dopamine may play some role in alcohol drinking, it is not the central substrate producing the reinforcement from ethanol in AA rats.