This study was supported in part by grants from the Jonathan Kellerman and Albert Marston Clinical Research Funds.
Children of Alcoholics Exhibit Attenuated Cognitive Impairment During an Ethanol Challenge
Article first published online: 30 MAY 2006
Alcoholism: Clinical and Experimental Research
Volume 23, Issue 3, pages 476–482, March 1999
How to Cite
Erblich, J. and Earleywine, M. (1999), Children of Alcoholics Exhibit Attenuated Cognitive Impairment During an Ethanol Challenge. Alcoholism: Clinical and Experimental Research, 23: 476–482. doi: 10.1111/j.1530-0277.1999.tb04140.x
- Issue published online: 30 MAY 2006
- Article first published online: 30 MAY 2006
- Received for publication April 13, 1998; accepted December 13, 1998.
In an attempt to identify markers potentially related to the development of problem drinking, we examined cognitive functioning in children of alcoholics (COAs) and children of nonalcoholics, both while sober and after consuming 0.85 ml/kg of ethanol. Consonant with previous research indicating that COAs exhibit less intense responses to alcohol, we predicted that COAs would experience attenuated cognitive deficits while intoxicated. Male (n= 71) and female (n= 29) college students completed tests of contextual and rote memory recall in a repeated-measures design. Findings indicated that intoxication impaired both memory and attentional capacities, and that COAs exhibited attenuated cognitive deficits relative to children of nonalcoholics. Results were consistent with previous research demonstrating attenuated responses to alcohol in COAs. Potential mechanisms for the pathogenesis of problem drinking are discussed.