This study was supported by U.S. Public Health Service Grants R37 AA06603 and P50AA11999, and by the Department of Veterans Affairs.
Cytokine Regulation of Hepatic Stellate Cells in Liver Fibrosis
Article first published online: 30 MAY 2006
Alcoholism: Clinical and Experimental Research
Volume 23, Issue 5, pages 911–916, May 1999
How to Cite
Tsukamoto, H. (1999), Cytokine Regulation of Hepatic Stellate Cells in Liver Fibrosis. Alcoholism: Clinical and Experimental Research, 23: 911–916. doi: 10.1111/j.1530-0277.1999.tb04202.x
- Issue published online: 30 MAY 2006
- Article first published online: 30 MAY 2006
- Ito Cells;
- Myofibroblastic Activation
Cytokines constitute a major class of mediators responsible for “activation” of hepatic stellate cells (HSCs) in vitro and in vivo. They are largely divided into mitogenic (transforming growth factor-α, platelet-derived growth factor, interleukin-1, tumor necrosis factor-α, and insulin-like growth factor) and fibrogenic (transforming growth factor-β and interleukin-6) cytokines. In addition to their mitogenic (stimulation of cell proliferation) and fibrogenic (induction of matrix proteins) properties, they are also shown to confer in vitro unique cellular changes known to be the key features of HSC “activation,” including loss of vitamin A, stimulation of migration, enhanced cellular contractility, and matrix metalloproteinase and tissue inhibitor of metalloproteinase induction. Potential cellular sources of the cytokines consist of hepatic macrophages, endothelial cells, biliary epithelial cells, lymphocytes, platelets, hepatocytes, and activated HSCs. To better understand the mode of actions and the pathogenetic significance of cytokineskhemokines involved in “activation” of HSCs, the following four questions need to be addressed: (1) What other cytokines are expressed by HSCs to establish critical autocrine stimulation? (2) What are endogenous or exogenous priming factors for HSC stimulation? (3) What is the mechanism of activation for transforming growth factor-β, the pivotal fibrogenic cytokine? (4) How important are HSC-derived proinflammatory mediators in liver fibrosis? This review will discuss these questions, along with the current understanding of the role of cytokines in HSC activation.