Genetic and Environmental Influences on Alcohol Metabolism in Humans

Authors

  • Ting-Kai Li,

    Corresponding author
    1. Department of Medicine (T-KL, DWC, VAR), Indiana University School of Medicine, Indianapolis, Indiana; National Defense Medical Center (S-JY), Taipei, Taiwan, Republic of China; and Department of Psychiatry (SO), Indiana University School of Medicine and the Veterans Affairs Medical Center, Indianapolis, Indiana.
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  • Shih-Jiun Yin,

    1. Department of Medicine (T-KL, DWC, VAR), Indiana University School of Medicine, Indianapolis, Indiana; National Defense Medical Center (S-JY), Taipei, Taiwan, Republic of China; and Department of Psychiatry (SO), Indiana University School of Medicine and the Veterans Affairs Medical Center, Indianapolis, Indiana.
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  • David W. Crabb,

    1. Department of Medicine (T-KL, DWC, VAR), Indiana University School of Medicine, Indianapolis, Indiana; National Defense Medical Center (S-JY), Taipei, Taiwan, Republic of China; and Department of Psychiatry (SO), Indiana University School of Medicine and the Veterans Affairs Medical Center, Indianapolis, Indiana.
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  • Sean O'Connor,

    1. Department of Medicine (T-KL, DWC, VAR), Indiana University School of Medicine, Indianapolis, Indiana; National Defense Medical Center (S-JY), Taipei, Taiwan, Republic of China; and Department of Psychiatry (SO), Indiana University School of Medicine and the Veterans Affairs Medical Center, Indianapolis, Indiana.
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  • Vijay A. Ramchandani

    1. Department of Medicine (T-KL, DWC, VAR), Indiana University School of Medicine, Indianapolis, Indiana; National Defense Medical Center (S-JY), Taipei, Taiwan, Republic of China; and Department of Psychiatry (SO), Indiana University School of Medicine and the Veterans Affairs Medical Center, Indianapolis, Indiana.
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  • Supported by NIAAA Grants R37-AA02342 and P50-AA07611 (T-KL, VAR); R01-AA06434, R01-AA11835, and P50-AA07611 (DWC); R21-AA10831, P50-AA07611, and M01-RR750 (SO); and National Science Council Grant 89-2314-B016-028 and National Health Research Institutes Grant GT-EX89B939P (S-JY).

Reprint requests: Ting-Kai Li, MD, Dept. of Medicine, Indiana University School of Medicine, 545 Barnhill Drive, Emerson 421, Indianapolis, IN 46202; Fax: 317-274-4311; E-mail: tkli@iupui.edu

Abstract

This manuscript represents the proceedings of a symposium at the 2000 RSA Meeting in Denver, Colorado. The organizer/chair was Ting-Kai Li. The presentations were: (1) Introduction to the Symposium, by Ting-Kai Li; (2) ALDH2 polymorphism and alcohol metabolism, by Shih-Jiun Yin; (3) ALDH2 promoter polymorphism and alcohol metabolism, by David W. Crabb; (4) Use of BrAC clamping to estimate alcohol elimination rates: Application to studies of the influence of genetic and environmental determinants, by Sean O'Connor; and (5) Effect of food and food composition on alcohol elimination rates as determined by clamping, by Vijay A. Ramchandani.

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