Effects of Alcohol and Oxidative Stress on Liver Pathology: The Role of the Mitochondrion

Authors

  • Alan Cahill,

    Corresponding author
    1. Department of Pathology, Anatomy and Cell Biology (AC, AD), Thomas Jefferson University, Philadelphia, Pennsylvania; Department of Biochemistry (CCC), Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Internal Medicine (MA, HI), School of Medicine, Keio University, Tokyo, Japan; Department of Environmental Health Sciences (SMB), School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama; and INSERM U-481 (BF), Hôpital Beaujon, Clichy Cedex, France.
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  • Carol C. Cunningham,

    1. Department of Pathology, Anatomy and Cell Biology (AC, AD), Thomas Jefferson University, Philadelphia, Pennsylvania; Department of Biochemistry (CCC), Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Internal Medicine (MA, HI), School of Medicine, Keio University, Tokyo, Japan; Department of Environmental Health Sciences (SMB), School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama; and INSERM U-481 (BF), Hôpital Beaujon, Clichy Cedex, France.
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  • Masayuki Adachi,

    1. Department of Pathology, Anatomy and Cell Biology (AC, AD), Thomas Jefferson University, Philadelphia, Pennsylvania; Department of Biochemistry (CCC), Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Internal Medicine (MA, HI), School of Medicine, Keio University, Tokyo, Japan; Department of Environmental Health Sciences (SMB), School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama; and INSERM U-481 (BF), Hôpital Beaujon, Clichy Cedex, France.
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  • Hiromasa Ishii,

    1. Department of Pathology, Anatomy and Cell Biology (AC, AD), Thomas Jefferson University, Philadelphia, Pennsylvania; Department of Biochemistry (CCC), Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Internal Medicine (MA, HI), School of Medicine, Keio University, Tokyo, Japan; Department of Environmental Health Sciences (SMB), School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama; and INSERM U-481 (BF), Hôpital Beaujon, Clichy Cedex, France.
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  • Shannon M. Bailey,

    1. Department of Pathology, Anatomy and Cell Biology (AC, AD), Thomas Jefferson University, Philadelphia, Pennsylvania; Department of Biochemistry (CCC), Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Internal Medicine (MA, HI), School of Medicine, Keio University, Tokyo, Japan; Department of Environmental Health Sciences (SMB), School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama; and INSERM U-481 (BF), Hôpital Beaujon, Clichy Cedex, France.
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  • Bernard Fromenty,

    1. Department of Pathology, Anatomy and Cell Biology (AC, AD), Thomas Jefferson University, Philadelphia, Pennsylvania; Department of Biochemistry (CCC), Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Internal Medicine (MA, HI), School of Medicine, Keio University, Tokyo, Japan; Department of Environmental Health Sciences (SMB), School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama; and INSERM U-481 (BF), Hôpital Beaujon, Clichy Cedex, France.
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  • Adrian Davies

    1. Department of Pathology, Anatomy and Cell Biology (AC, AD), Thomas Jefferson University, Philadelphia, Pennsylvania; Department of Biochemistry (CCC), Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Internal Medicine (MA, HI), School of Medicine, Keio University, Tokyo, Japan; Department of Environmental Health Sciences (SMB), School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama; and INSERM U-481 (BF), Hôpital Beaujon, Clichy Cedex, France.
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Dr. Alan Cahill, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St., Philadelphia, PA 19107; Fax: 215-923-2218; E-mail: alan.cahill@mail.tju.edu

Abstract

This article represents the proceedings of a symposium at the 2001 Research Society on Alcoholism meeting in Montreal, Canada. The chairs were Alan Cahill and Carol C. Cunningham. The presentations were (1) Mitochondrial regulation of ethanol-induced hepatocyte apoptosis: possible involvement of proapoptotic Bcl-2 family protein Bax, by Masayuki Adachi and Hiromasa Ishii; (2) Effects of ethanol on mitochondrial reactive oxygen species production and oxidative protein modification, by Shannon M. Bailey; (3) Acute ethanol binges elicit widespread oxidative mitochondrial DNA damage and depletion: protective effects of antioxidants and inhibitors of ethanol metabolism, by Bernard Fromenty; and (4) Effects of chronic ethanol consumption upon hepatic mtDNA oxidative modification and depletion, by Alan Cahill and Adrian Davies.

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