Effects of Alcohol and Oxidative Stress on Liver Pathology: The Role of the Mitochondrion
Article first published online: 11 APR 2006
Alcoholism: Clinical and Experimental Research
Volume 26, Issue 6, pages 907–915, June 2002
How to Cite
Cahill, A., Cunningham, C. C., Adachi, M., Ishii, H., Bailey, S. M., Fromenty, B. and Davies, A. (2002), Effects of Alcohol and Oxidative Stress on Liver Pathology: The Role of the Mitochondrion. Alcoholism: Clinical and Experimental Research, 26: 907–915. doi: 10.1111/j.1530-0277.2002.tb02621.x
- Issue published online: 11 APR 2006
- Article first published online: 11 APR 2006
- Received for publication February 11, 2002; accepted March 27, 2002.
- Oxidative Stress;
- Mitochondrial DNA;
This article represents the proceedings of a symposium at the 2001 Research Society on Alcoholism meeting in Montreal, Canada. The chairs were Alan Cahill and Carol C. Cunningham. The presentations were (1) Mitochondrial regulation of ethanol-induced hepatocyte apoptosis: possible involvement of proapoptotic Bcl-2 family protein Bax, by Masayuki Adachi and Hiromasa Ishii; (2) Effects of ethanol on mitochondrial reactive oxygen species production and oxidative protein modification, by Shannon M. Bailey; (3) Acute ethanol binges elicit widespread oxidative mitochondrial DNA damage and depletion: protective effects of antioxidants and inhibitors of ethanol metabolism, by Bernard Fromenty; and (4) Effects of chronic ethanol consumption upon hepatic mtDNA oxidative modification and depletion, by Alan Cahill and Adrian Davies.