Brain Activation Elicited by Affectively Positive Stimuli Is Associated With a Lower Risk of Relapse in Detoxified Alcoholic Subjects

  1. Andreas Heinz1,3,†,
  2. Jana Wrase1,†,
  3. Thorsten Kahnt1,
  4. Anne Beck1,
  5. Zohra Bromand1,
  6. Sabine M. Grüsser2,
  7. Thorsten Kienast1,
  8. Michael N. Smolka3,5,
  9. Herta Flor4,
  10. Karl Mann3

Article first published online: 4 MAY 2007

DOI: 10.1111/j.1530-0277.2007.00406.x

Issue

Alcoholism: Clinical and Experimental Research

Alcoholism: Clinical and Experimental Research

Volume 31, Issue 7, pages 1138–1147, July 2007

Additional Information

How to Cite

Heinz, A., Wrase, J., Kahnt, T., Beck, A., Bromand, Z., Grüsser, S. M., Kienast, T., Smolka, M. N., Flor, H. and Mann, K. (2007), Brain Activation Elicited by Affectively Positive Stimuli Is Associated With a Lower Risk of Relapse in Detoxified Alcoholic Subjects. Alcoholism: Clinical and Experimental Research, 31: 1138–1147. doi: 10.1111/j.1530-0277.2007.00406.x

Author Information

  1. 1

    Department of Psychiatry, Charité—University Medical Center Berlin, CCM, Berlin, Germany

  2. 2

    Department of Medical Psychology, Charité—University Medical Center Berlin, CCM, Berlin, Germany

  3. 3

    Department for Addiction Research and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Heidelberg, Germany

  4. 4

    Department of Psychology, Central Institute of Mental Health, University of Heidelberg, Heidelberg, Germany

  5. 5

    Department of Psychiatry, Technische Universität Dresden, Dresden, Germany

  1. †

    *Equal contribution.

*Reprint requests: Andreas Heinz, MD, Department of Psychiatry, Charité—University Medical Center Berlin, Charité Campus Mitte, Charitéplatz 1, Berlin 10117, Germany; Fax: 49-30-450517910; E-Mail: andreas.heinz@charite.de

  1. This work was funded by the Deutsche Forschungsgemeinschaft (He 2597/4-3) and by the Bernstein Center for Computational Neuroscience Berlin (BMBF Grant 01GQ0411) as well as BMBF Grant 01EB0410-6.

  2. †

    *Equal contribution.

Publication History

  1. Issue published online: 4 MAY 2007
  2. Article first published online: 4 MAY 2007
  3. Received for publication August 2, 2006; accepted March 7, 2007.

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Table S2. Cue-induced brain activation in alcoholics and healthy controls elicited by affectively positive > neutral stimuli. Threshold was p<0.001 uncorrected and a voxel threshold of at least 5 activated voxels. In the table, x, y, z represent coordinates in the stereotactic atlas of Talairach and Tournoux.

Table S3. Cue-induced brain activation in alcoholics and healthy controls elicited by affectively negative > neutral stimuli. Threshold was p<0.001 uncorrected and a voxel threshold of at least 5 active voxels. In the table, x, y, z represent coordinates in the stereotactic atlas of Talairach and Tournoux.

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