Lack of Association of Alcohol Dependence and Habitual Smoking With Catechol-O-methyltransferase

Authors

  • Tatiana Foroud,

    1. From the Indiana University School of Medicine (TF, LFW, JIN, XX, HJE), Indianapolis, Indiana; Washington University School of Medicine (DMD, LJB), St Louis, Missouri; University of Connecticut School of Medicine (VH), Farmington, Connecticut; University of Iowa Carver College of Medicine (JK), Iowa City, Iowa; Rutgers University, Human Genetics Institute (JT), Piscataway, New Jersy; and University of California (MS), San Diego, California.
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  • Leah Flury Wetherill,

    1. From the Indiana University School of Medicine (TF, LFW, JIN, XX, HJE), Indianapolis, Indiana; Washington University School of Medicine (DMD, LJB), St Louis, Missouri; University of Connecticut School of Medicine (VH), Farmington, Connecticut; University of Iowa Carver College of Medicine (JK), Iowa City, Iowa; Rutgers University, Human Genetics Institute (JT), Piscataway, New Jersy; and University of California (MS), San Diego, California.
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  • Danielle M. Dick,

    1. From the Indiana University School of Medicine (TF, LFW, JIN, XX, HJE), Indianapolis, Indiana; Washington University School of Medicine (DMD, LJB), St Louis, Missouri; University of Connecticut School of Medicine (VH), Farmington, Connecticut; University of Iowa Carver College of Medicine (JK), Iowa City, Iowa; Rutgers University, Human Genetics Institute (JT), Piscataway, New Jersy; and University of California (MS), San Diego, California.
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  • Victor Hesselbrock,

    1. From the Indiana University School of Medicine (TF, LFW, JIN, XX, HJE), Indianapolis, Indiana; Washington University School of Medicine (DMD, LJB), St Louis, Missouri; University of Connecticut School of Medicine (VH), Farmington, Connecticut; University of Iowa Carver College of Medicine (JK), Iowa City, Iowa; Rutgers University, Human Genetics Institute (JT), Piscataway, New Jersy; and University of California (MS), San Diego, California.
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  • John I. Nurnberger, Jr,

    1. From the Indiana University School of Medicine (TF, LFW, JIN, XX, HJE), Indianapolis, Indiana; Washington University School of Medicine (DMD, LJB), St Louis, Missouri; University of Connecticut School of Medicine (VH), Farmington, Connecticut; University of Iowa Carver College of Medicine (JK), Iowa City, Iowa; Rutgers University, Human Genetics Institute (JT), Piscataway, New Jersy; and University of California (MS), San Diego, California.
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  • John Kramer,

    1. From the Indiana University School of Medicine (TF, LFW, JIN, XX, HJE), Indianapolis, Indiana; Washington University School of Medicine (DMD, LJB), St Louis, Missouri; University of Connecticut School of Medicine (VH), Farmington, Connecticut; University of Iowa Carver College of Medicine (JK), Iowa City, Iowa; Rutgers University, Human Genetics Institute (JT), Piscataway, New Jersy; and University of California (MS), San Diego, California.
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  • Jay Tischfield,

    1. From the Indiana University School of Medicine (TF, LFW, JIN, XX, HJE), Indianapolis, Indiana; Washington University School of Medicine (DMD, LJB), St Louis, Missouri; University of Connecticut School of Medicine (VH), Farmington, Connecticut; University of Iowa Carver College of Medicine (JK), Iowa City, Iowa; Rutgers University, Human Genetics Institute (JT), Piscataway, New Jersy; and University of California (MS), San Diego, California.
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  • Marc Schuckit,

    1. From the Indiana University School of Medicine (TF, LFW, JIN, XX, HJE), Indianapolis, Indiana; Washington University School of Medicine (DMD, LJB), St Louis, Missouri; University of Connecticut School of Medicine (VH), Farmington, Connecticut; University of Iowa Carver College of Medicine (JK), Iowa City, Iowa; Rutgers University, Human Genetics Institute (JT), Piscataway, New Jersy; and University of California (MS), San Diego, California.
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  • Laura J. Bierut,

    1. From the Indiana University School of Medicine (TF, LFW, JIN, XX, HJE), Indianapolis, Indiana; Washington University School of Medicine (DMD, LJB), St Louis, Missouri; University of Connecticut School of Medicine (VH), Farmington, Connecticut; University of Iowa Carver College of Medicine (JK), Iowa City, Iowa; Rutgers University, Human Genetics Institute (JT), Piscataway, New Jersy; and University of California (MS), San Diego, California.
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  • Xiaoling Xuei,

    1. From the Indiana University School of Medicine (TF, LFW, JIN, XX, HJE), Indianapolis, Indiana; Washington University School of Medicine (DMD, LJB), St Louis, Missouri; University of Connecticut School of Medicine (VH), Farmington, Connecticut; University of Iowa Carver College of Medicine (JK), Iowa City, Iowa; Rutgers University, Human Genetics Institute (JT), Piscataway, New Jersy; and University of California (MS), San Diego, California.
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  • Howard J. Edenberg

    1. From the Indiana University School of Medicine (TF, LFW, JIN, XX, HJE), Indianapolis, Indiana; Washington University School of Medicine (DMD, LJB), St Louis, Missouri; University of Connecticut School of Medicine (VH), Farmington, Connecticut; University of Iowa Carver College of Medicine (JK), Iowa City, Iowa; Rutgers University, Human Genetics Institute (JT), Piscataway, New Jersy; and University of California (MS), San Diego, California.
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Reprint requests: Tatiana Foroud, PhD, Indiana University School of Medicine, Health Information and Translational Sciences HS 4000, 410 West 10th Street, Indianapolis, IN 46202-3002; Fax: (317)-278-1100; E-mail: tforoud@iupui.edu

Abstract

Objective:  To test whether variation in the gene encoding the enzyme catechol-O-methyltransferase (COMT), which catalyzes the breakdown of dopamine and other catecholamine neurotransmitters, is associated with the risk for alcohol dependence and habitual smoking.

Methods:  Single nucleotide polymophisms (SNPs) were genotyped in a sample of 219 multiplex alcohol-dependent families of European American descent from the Collaborative Study on the Genetics of Alcoholism (COGA). Family-based tests of association were performed to evaluate the evidence of association between the 18 SNPs distributed throughout COMT, including the functional Val158Met polymorphism, and the phenotypes of alcohol dependence, early onset alcohol dependence, habitual smoking, and comorbid alcohol dependence and habitual smoking.

Results:  No significant, consistent evidence of association was found with alcohol dependence, early onset alcohol dependence, habitual smoking or the comorbid phenotype. There was no evidence that the functional Val158Met polymorphism, previously reported to be associated with these phenotypes, was associated with any of them.

Conclusion:  Despite the substantial size of this study, we did not find evidence to support an association between alcohol dependence or habitual smoking and variation in COMT.

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