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The Association Between Alcohol Consumption and Biomarkers of Alcohol Exposure With Total Serum Immunoglobulin E Levels

Authors

  • Nele Friedrich,

    1. Institute for Community Medicine, Ernst Moritz Arndt University, Greifswald, Germany (NF, HV); Research Centre for Prevention and Health, The Capital Region of Denmark, Denmark (NF, LLNH, AL); and Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University, Greifswald, Germany (AP, MN).
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  • Lise Lotte N. Husemoen,

    1. Institute for Community Medicine, Ernst Moritz Arndt University, Greifswald, Germany (NF, HV); Research Centre for Prevention and Health, The Capital Region of Denmark, Denmark (NF, LLNH, AL); and Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University, Greifswald, Germany (AP, MN).
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  • Astrid Petersmann,

    1. Institute for Community Medicine, Ernst Moritz Arndt University, Greifswald, Germany (NF, HV); Research Centre for Prevention and Health, The Capital Region of Denmark, Denmark (NF, LLNH, AL); and Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University, Greifswald, Germany (AP, MN).
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  • Matthias Nauck,

    1. Institute for Community Medicine, Ernst Moritz Arndt University, Greifswald, Germany (NF, HV); Research Centre for Prevention and Health, The Capital Region of Denmark, Denmark (NF, LLNH, AL); and Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University, Greifswald, Germany (AP, MN).
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  • Henry Völzke,

    1. Institute for Community Medicine, Ernst Moritz Arndt University, Greifswald, Germany (NF, HV); Research Centre for Prevention and Health, The Capital Region of Denmark, Denmark (NF, LLNH, AL); and Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University, Greifswald, Germany (AP, MN).
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  • Allan Linneberg

    1. Institute for Community Medicine, Ernst Moritz Arndt University, Greifswald, Germany (NF, HV); Research Centre for Prevention and Health, The Capital Region of Denmark, Denmark (NF, LLNH, AL); and Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University, Greifswald, Germany (AP, MN).
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Reprint requests: Nele Friedrich, Institute for Community Medicine, Ernst Moritz Arndt University, Walther-Rathenau-Str. 48, D-17487 Greifswald, Germany; Fax: +49-3834-866684; E-mail: nele.friedrich@uni-greifswald.de

Abstract

Background:  A number of studies have shown that self-reported alcohol intake is positively associated with total serum immunoglobin E (IgE) levels. The purpose of the present study was to investigate the association of self-reported alcohol consumption and different biomarkers of alcohol exposure to total serum IgE levels in a general adult population.

Methods:  A total of 3,443 subjects aged 20 to 79 years from the population-based cross-sectional Study of Health in Pomerania (SHIP) were included in the analyses. Information on alcohol consumption and serum carbohydrate-deficient transferrin (CDT), gamma-glutamyl transferase (GGT), aspartate-amino transferase (ASAT), andalanine-amino transferase (ALAT) levels were measured. Multivariable linear regression models were performed separately in atopic and nonatopic subjects.

Results:  In nonatopic subjects positive associations between self-reported alcohol consumption as well as all considered biomarkers of alcohol exposure and total serum IgE levels were found. Further the results also suggested positive associations between alcohol consumption as well as alcohol biomarkers and total serum IgE level in atopic subjects, even though not all tests for linear trend reached statistical significance.

Conclusions:  In conclusion, biomarkers of alcohol exposure were positively associated with total serum IgE levels supporting that the positive association between self-reported alcohol intake and IgE levels observed in previous studies is real and not due to misclassification of alcohol intake or confounding by other factors that may be linked to both alcohol intake and total serum IgE levels.

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