MAOA-uVNTR Polymorphism May Modify the Protective Effect of ALDH2 Gene Against Alcohol Dependence in Antisocial Personality Disorder

Authors

  • Sheng-Yu Lee,

    1. From the Institute of Behavioral Medicine (S-YL, S-HC, H-CK, R-BL); Department of Psychiatry (C-YH, S-LC, TLY, IHL, YKY, R-BL); Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (C-YH, P-HK); Department of Psychiatry, National Cheng Kung University Hospital (S-YL, C-YH, TLY, IHL, YKY, R-BL), Tainan; Armed Forces Pei-Tou Hospital (J-FL); Department of Psychiatry (S-YH), Tri-Service General Hospital, National Defense Medical Center; Taipei, Taiwan, Republic of China.
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  • Cheng-Yi Hahn,

    1. From the Institute of Behavioral Medicine (S-YL, S-HC, H-CK, R-BL); Department of Psychiatry (C-YH, S-LC, TLY, IHL, YKY, R-BL); Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (C-YH, P-HK); Department of Psychiatry, National Cheng Kung University Hospital (S-YL, C-YH, TLY, IHL, YKY, R-BL), Tainan; Armed Forces Pei-Tou Hospital (J-FL); Department of Psychiatry (S-YH), Tri-Service General Hospital, National Defense Medical Center; Taipei, Taiwan, Republic of China.
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  • Jia-Fu Lee,

    1. From the Institute of Behavioral Medicine (S-YL, S-HC, H-CK, R-BL); Department of Psychiatry (C-YH, S-LC, TLY, IHL, YKY, R-BL); Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (C-YH, P-HK); Department of Psychiatry, National Cheng Kung University Hospital (S-YL, C-YH, TLY, IHL, YKY, R-BL), Tainan; Armed Forces Pei-Tou Hospital (J-FL); Department of Psychiatry (S-YH), Tri-Service General Hospital, National Defense Medical Center; Taipei, Taiwan, Republic of China.
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  • Shiou-Lan Chen,

    1. From the Institute of Behavioral Medicine (S-YL, S-HC, H-CK, R-BL); Department of Psychiatry (C-YH, S-LC, TLY, IHL, YKY, R-BL); Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (C-YH, P-HK); Department of Psychiatry, National Cheng Kung University Hospital (S-YL, C-YH, TLY, IHL, YKY, R-BL), Tainan; Armed Forces Pei-Tou Hospital (J-FL); Department of Psychiatry (S-YH), Tri-Service General Hospital, National Defense Medical Center; Taipei, Taiwan, Republic of China.
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  • Shih-Heng Chen,

    1. From the Institute of Behavioral Medicine (S-YL, S-HC, H-CK, R-BL); Department of Psychiatry (C-YH, S-LC, TLY, IHL, YKY, R-BL); Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (C-YH, P-HK); Department of Psychiatry, National Cheng Kung University Hospital (S-YL, C-YH, TLY, IHL, YKY, R-BL), Tainan; Armed Forces Pei-Tou Hospital (J-FL); Department of Psychiatry (S-YH), Tri-Service General Hospital, National Defense Medical Center; Taipei, Taiwan, Republic of China.
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  • Tzung Lieh Yeh,

    1. From the Institute of Behavioral Medicine (S-YL, S-HC, H-CK, R-BL); Department of Psychiatry (C-YH, S-LC, TLY, IHL, YKY, R-BL); Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (C-YH, P-HK); Department of Psychiatry, National Cheng Kung University Hospital (S-YL, C-YH, TLY, IHL, YKY, R-BL), Tainan; Armed Forces Pei-Tou Hospital (J-FL); Department of Psychiatry (S-YH), Tri-Service General Hospital, National Defense Medical Center; Taipei, Taiwan, Republic of China.
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  • Po-Hsiu Kuo,

    1. From the Institute of Behavioral Medicine (S-YL, S-HC, H-CK, R-BL); Department of Psychiatry (C-YH, S-LC, TLY, IHL, YKY, R-BL); Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (C-YH, P-HK); Department of Psychiatry, National Cheng Kung University Hospital (S-YL, C-YH, TLY, IHL, YKY, R-BL), Tainan; Armed Forces Pei-Tou Hospital (J-FL); Department of Psychiatry (S-YH), Tri-Service General Hospital, National Defense Medical Center; Taipei, Taiwan, Republic of China.
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  • I Hui Lee,

    1. From the Institute of Behavioral Medicine (S-YL, S-HC, H-CK, R-BL); Department of Psychiatry (C-YH, S-LC, TLY, IHL, YKY, R-BL); Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (C-YH, P-HK); Department of Psychiatry, National Cheng Kung University Hospital (S-YL, C-YH, TLY, IHL, YKY, R-BL), Tainan; Armed Forces Pei-Tou Hospital (J-FL); Department of Psychiatry (S-YH), Tri-Service General Hospital, National Defense Medical Center; Taipei, Taiwan, Republic of China.
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  • Yen Kuang Yang,

    1. From the Institute of Behavioral Medicine (S-YL, S-HC, H-CK, R-BL); Department of Psychiatry (C-YH, S-LC, TLY, IHL, YKY, R-BL); Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (C-YH, P-HK); Department of Psychiatry, National Cheng Kung University Hospital (S-YL, C-YH, TLY, IHL, YKY, R-BL), Tainan; Armed Forces Pei-Tou Hospital (J-FL); Department of Psychiatry (S-YH), Tri-Service General Hospital, National Defense Medical Center; Taipei, Taiwan, Republic of China.
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  • San-Yuan Huang,

    1. From the Institute of Behavioral Medicine (S-YL, S-HC, H-CK, R-BL); Department of Psychiatry (C-YH, S-LC, TLY, IHL, YKY, R-BL); Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (C-YH, P-HK); Department of Psychiatry, National Cheng Kung University Hospital (S-YL, C-YH, TLY, IHL, YKY, R-BL), Tainan; Armed Forces Pei-Tou Hospital (J-FL); Department of Psychiatry (S-YH), Tri-Service General Hospital, National Defense Medical Center; Taipei, Taiwan, Republic of China.
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  • Huei-Chen Ko,

    1. From the Institute of Behavioral Medicine (S-YL, S-HC, H-CK, R-BL); Department of Psychiatry (C-YH, S-LC, TLY, IHL, YKY, R-BL); Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (C-YH, P-HK); Department of Psychiatry, National Cheng Kung University Hospital (S-YL, C-YH, TLY, IHL, YKY, R-BL), Tainan; Armed Forces Pei-Tou Hospital (J-FL); Department of Psychiatry (S-YH), Tri-Service General Hospital, National Defense Medical Center; Taipei, Taiwan, Republic of China.
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  • Ru-Band Lu

    1. From the Institute of Behavioral Medicine (S-YL, S-HC, H-CK, R-BL); Department of Psychiatry (C-YH, S-LC, TLY, IHL, YKY, R-BL); Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (C-YH, P-HK); Department of Psychiatry, National Cheng Kung University Hospital (S-YL, C-YH, TLY, IHL, YKY, R-BL), Tainan; Armed Forces Pei-Tou Hospital (J-FL); Department of Psychiatry (S-YH), Tri-Service General Hospital, National Defense Medical Center; Taipei, Taiwan, Republic of China.
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Reprint requests: Ru-Band Lu, MD, Department of Psychiatry, College of Medicine & Hospital, National Cheng Kung University, No. 138, Sheng-Li Road, 70428, Tainan, Taiwan, Republic of China; Fax: +886 6 302-8012; E-mail: rblu@mail.ncku.edu.tw, rubandlu@gmail.com

Abstract

Background:  Antisocial alcoholism is related to dopamine and serotonin which are catalyzed by monoamine oxidase A (MAOA) and acetaldehyde dehydrogenase 2 (ALDH2). The objective of this study is to determine whether the interaction between the MAOA and the ALDH2 genes is associated with subjects with antisocial personality disorder (ASPD) having alcoholism.

Methods:  A total of 294 Han Chinese men in Taiwan including 132 ASPD with alcoholism (Antisocial ALC) and 162 without alcoholism (Antisocial Non-ALC) were recruited in this study. Alcohol dependence and ASPD were diagnosed according to DSM-IV criteria. Genotypes of ALDH2 and MAOA-uVNTR were determined using PCR-RFLP.

Results:  A significant difference of ALDH2 polymorphisms (p = 3.39E-05), but not of MAOA, was found among the 2 study groups. However, only after the stratification of the MAOA-uVNTR (variable number of tandem repeat located upstream) 3-repeat, a significant association between Antisocial Non-ALC and ALDH2*1/*2 or *2/*2 genotypes was shown (p = 1.46E–05; odds ratio = 3.913); whereas stratification of MAOA-uVNTR 4-repeat revealed no association. Multiple logistic regression analysis further revealed significant interaction of MAOA and ALDH2 gene in antisocial ALC (odds ratio = 2.927; = 0.032).

Conclusion:  The possible interaction of MAOA and ALDH2 gene is associated with Antisocial ALC in Han Chinese males in Taiwan. However, the protective effects of the ALDH2*2 allele against alcoholism might disappear in subjects with ASPD and carrying MAOA-uVNTR 4-repeat allele in the Han Chinese male population.

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