The Relationship Between Serotonin Receptor 1B Polymorphisms A-161T and Alcohol Dependence

Authors

  • Sheng-Yu Lee,

    1. From the Institute of Behavioral Medicine, College of Medicine (S-YL, C-LW, P-LW, H-CK, R-BL), National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry (S-YL, R-BL), National Cheng Kung University Hospital, Tainan, Taiwan; Department of Psychiatry, Tri-Service General Hospital (W-WL, S-YH), National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Clinical Medicine (P-HK); Department of Psychiatry (S-LC, R-BL); Institute of Allied Health Sciences, College of Medicine (JY-WW, H-CK), National Cheng Kung University, Tainan, Taiwan, China.
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  • Wei-Wen Lin,

    1. From the Institute of Behavioral Medicine, College of Medicine (S-YL, C-LW, P-LW, H-CK, R-BL), National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry (S-YL, R-BL), National Cheng Kung University Hospital, Tainan, Taiwan; Department of Psychiatry, Tri-Service General Hospital (W-WL, S-YH), National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Clinical Medicine (P-HK); Department of Psychiatry (S-LC, R-BL); Institute of Allied Health Sciences, College of Medicine (JY-WW, H-CK), National Cheng Kung University, Tainan, Taiwan, China.
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  • San-Yuan Huang,

    1. From the Institute of Behavioral Medicine, College of Medicine (S-YL, C-LW, P-LW, H-CK, R-BL), National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry (S-YL, R-BL), National Cheng Kung University Hospital, Tainan, Taiwan; Department of Psychiatry, Tri-Service General Hospital (W-WL, S-YH), National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Clinical Medicine (P-HK); Department of Psychiatry (S-LC, R-BL); Institute of Allied Health Sciences, College of Medicine (JY-WW, H-CK), National Cheng Kung University, Tainan, Taiwan, China.
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  • Po-Hsiu Kuo,

    1. From the Institute of Behavioral Medicine, College of Medicine (S-YL, C-LW, P-LW, H-CK, R-BL), National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry (S-YL, R-BL), National Cheng Kung University Hospital, Tainan, Taiwan; Department of Psychiatry, Tri-Service General Hospital (W-WL, S-YH), National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Clinical Medicine (P-HK); Department of Psychiatry (S-LC, R-BL); Institute of Allied Health Sciences, College of Medicine (JY-WW, H-CK), National Cheng Kung University, Tainan, Taiwan, China.
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  • Chen-Lin Wang,

    1. From the Institute of Behavioral Medicine, College of Medicine (S-YL, C-LW, P-LW, H-CK, R-BL), National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry (S-YL, R-BL), National Cheng Kung University Hospital, Tainan, Taiwan; Department of Psychiatry, Tri-Service General Hospital (W-WL, S-YH), National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Clinical Medicine (P-HK); Department of Psychiatry (S-LC, R-BL); Institute of Allied Health Sciences, College of Medicine (JY-WW, H-CK), National Cheng Kung University, Tainan, Taiwan, China.
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  • Pei-Lin Wu,

    1. From the Institute of Behavioral Medicine, College of Medicine (S-YL, C-LW, P-LW, H-CK, R-BL), National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry (S-YL, R-BL), National Cheng Kung University Hospital, Tainan, Taiwan; Department of Psychiatry, Tri-Service General Hospital (W-WL, S-YH), National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Clinical Medicine (P-HK); Department of Psychiatry (S-LC, R-BL); Institute of Allied Health Sciences, College of Medicine (JY-WW, H-CK), National Cheng Kung University, Tainan, Taiwan, China.
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  • Shiou-Lan Chen,

    1. From the Institute of Behavioral Medicine, College of Medicine (S-YL, C-LW, P-LW, H-CK, R-BL), National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry (S-YL, R-BL), National Cheng Kung University Hospital, Tainan, Taiwan; Department of Psychiatry, Tri-Service General Hospital (W-WL, S-YH), National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Clinical Medicine (P-HK); Department of Psychiatry (S-LC, R-BL); Institute of Allied Health Sciences, College of Medicine (JY-WW, H-CK), National Cheng Kung University, Tainan, Taiwan, China.
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  • Jo Yung-Wei Wu,

    1. From the Institute of Behavioral Medicine, College of Medicine (S-YL, C-LW, P-LW, H-CK, R-BL), National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry (S-YL, R-BL), National Cheng Kung University Hospital, Tainan, Taiwan; Department of Psychiatry, Tri-Service General Hospital (W-WL, S-YH), National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Clinical Medicine (P-HK); Department of Psychiatry (S-LC, R-BL); Institute of Allied Health Sciences, College of Medicine (JY-WW, H-CK), National Cheng Kung University, Tainan, Taiwan, China.
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  • Huei-Chen Ko,

    1. From the Institute of Behavioral Medicine, College of Medicine (S-YL, C-LW, P-LW, H-CK, R-BL), National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry (S-YL, R-BL), National Cheng Kung University Hospital, Tainan, Taiwan; Department of Psychiatry, Tri-Service General Hospital (W-WL, S-YH), National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Clinical Medicine (P-HK); Department of Psychiatry (S-LC, R-BL); Institute of Allied Health Sciences, College of Medicine (JY-WW, H-CK), National Cheng Kung University, Tainan, Taiwan, China.
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  • Ru-Band Lu

    1. From the Institute of Behavioral Medicine, College of Medicine (S-YL, C-LW, P-LW, H-CK, R-BL), National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry (S-YL, R-BL), National Cheng Kung University Hospital, Tainan, Taiwan; Department of Psychiatry, Tri-Service General Hospital (W-WL, S-YH), National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Clinical Medicine (P-HK); Department of Psychiatry (S-LC, R-BL); Institute of Allied Health Sciences, College of Medicine (JY-WW, H-CK), National Cheng Kung University, Tainan, Taiwan, China.
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Reprint requests: Dr. Ru-Band Lu, Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, No. 138, Sheng-Li Road, 70428, Tainan, Taiwan, China; Fax: 886-6-302-8012; E-mail: rblu@mail.ncku.edu.tw

Abstract

Background:  Several studies have suggested that the serotonin receptor 1B gene (5HT1B) may be important in the pathogenesis of alcohol dependence (alcoholism; ALC; AD). We examined whether 5HT1B gene A-161T polymorphisms (rs130058) are a susceptibility factor for total AD and subgroups of AD. We further explored correlation of this 5HT1B gene variant between anxiety–depression alcoholism (ANX/DEP ALC) and antisocial alcoholism (antisocial ALC) subgroups because of the high comorbidity of anxiety–depression, antisocial personality disorder, and AD.

Methods:  We recruited 522 Han Chinese in Taiwan for this study: 322 AD patients and 200 controls. The patient group was recruited primarily from medical teaching hospitals; patients with antisocial alcoholism were recruited from Taiwanese prisons. Individuals with AD were classified into 3 homogeneous clinical subgroups—pure alcoholism (pure ALC), ANX/DEP ALC, and antisocial ALC—using DSM-IV diagnosis. The 5HT1B gene A-161T polymorphism was determined using PCR–RFLP.

Results:  No significant differences in genotypic and allelic frequencies were found between controls and the total AD group or between controls and the 3 AD subgroups. However, there were significant differences in the 5HT1B gene A-161T polymorphism at both the genotype and allelic levels between the ANX/DEP ALC and antisocial ALC subgroups.

Conclusions:  This study suggests that the 5HT1B gene A-161T polymorphism alone is not a risk factor for increasing susceptibility to either AD or its subtypes. However, 5HT1B gene A-161T polymorphisms might be one of the common genetic factors between the ANX/DEP ALC and antisocial ALC subgroups.

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