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References

  • Almasy L (2003) Quantitative risk factors as indices of alcoholism susceptibility. Ann Med 35(5):337343.
  • Ambrosini A, Bresciani L, Fracchia S, Brunello N, Racagni G (1995) Metabotropic glutamate receptors negatively coupled to adenylate cyclase inhibit N-methyl-D-aspartate receptor activity and prevent neurotoxicity in mesencephalic neurons in vitro. Mol Pharmacol 47(5):10571064.
  • AmericanPsychiatricAssociation (2000) American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Text Revision, (DSM-IV-TR). American Psychiatric Press, Arlington, VA.
  • Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25(1):2529.
  • Atkinson B, Therneau T (2008) Kinship: mixed-effects Cox models, sparse matrices, and modeling data from large pedigrees. R package version 1.1.0-21. Available at: http://cran.rproject.org/web/packages/kinship/index.html.
  • Baldwin HA, Wall TL, Schuckit MA, Koob GF (1991) Differential effects of ethanol on punished responding in the P and NP rats. Alcohol Clin Exp Res 15(4):700704.
  • Bannerman DM, Good MA, Butcher SP, Ramsay M, Morris RG (1995) Distinct components of spatial learning revealed by prior training and NMDA receptor blockade. Nature 378(6553):182186.
  • Bartkuhn M, Renkawitz R (2008) Long range chromatin interactions involved in gene regulation. Biochim Biophys Acta 1783(11):21612166.
  • Benjamini Y, Yekutieli D (2001) The control of the false discovery rate in multiple testing under dependency. Ann Stat 29:00905364.
  • Bierut LJ, Saccone NL, Rice JP, Goate A, Foroud T, Edenberg H, Almasy L, Conneally PM, Crowe R, Hesselbrock V, Li TK, Nurnberger J Jr, Porjesz B, Schuckit MA, Tischfield J, Begleiter H, Reich T (2002) Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of Alcoholism. Alcohol Res Health 26(3):208213.
  • Box GEP, Cox DR (1964) An analysis of transformations (with discussion). J R Stat Soc B 26:211252.
  • Bucholz KK, Cadoret R, Cloninger CR, Dinwiddie SH, Hesselbrock VM, Nurnberger JI Jr, Reich T, Schmidt I, Schuckit MA (1994) A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. J Stud Alcohol 55(2):149158.
  • Chen AC, Tang Y, Rangaswamy M, Wang JC, Almasy L, Foroud T, Edenberg HJ, Hesselbrock V, Nurnberger J Jr, Kuperman S, O’Connor SJ, Schuckit MA, Bauer LO, Tischfield J, Rice JP, Bierut L, Goate A, Porjesz B (2009) Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence. Am J Med Genet B Neuropsychiatr Genet 150B(3):359368.
  • Collingridge GL, Lester RA (1989) Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol Rev 41(2):143210.
  • Costa ET, Soto EE, Cardoso RA, Olivera DS, Valenzuela CF (2000) Acute effects of ethanol on kainate receptors in cultured hippocampal neurons. Alcohol Clin Exp Res 24(2):220225.
  • Curtis RK, Oresic M, Vidal-Puig A (2005) Pathways to the analysis of microarray data. Trends Biotechnol 23(8):429435.
  • Dahlquist KD, Salomonis N, Vranizan K, Lawlor SC, Conklin BR (2002) GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways. Nat Genet 31(1):1920.
  • Erblich J, Earleywine M (1999) Children of alcoholics exhibit attenuated cognitive impairment during an ethanol challenge. Alcohol Clin Exp Res 23(3):476482.
  • Feltenstein MW, See RE (2008) The neurocircuitry of addiction: an overview. Br J Pharmacol 154(2):261274.
  • Ferrani-Kile K, Leslie SW (2005) Modulation of protein tyrosine phosphatase activity alters the subunit assembly in native N-methyl-D-aspartate receptor complex. J Pharmacol Exp Ther 314(1):8693.
  • Goeman JJ, Buhlmann P (2007) Analyzing gene expression data in terms of gene sets: methodological issues. Bioinformatics 23(8):980987.
  • Goldman D, Oroszi G, Ducci F (2005) The genetics of addictions: uncovering the genes. Nat Rev Genet 6(7):521532.
  • Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160(4):636645.
  • Gryder DS, Rogawski MA (2003) Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons. J Neurosci 23(18):70697074.
  • Heath AC, Martin NG (1992) Genetic differences in psychomotor performance decrement after alcohol: a multivariate analysis. J Stud Alcohol 53(3):262271.
  • Hesselbrock M, Easton C, Bucholz KK, Schuckit M, Hesselbrock V (1999) A validity study of the SSAGA—a comparison with the SCAN. Addiction 94(9):13611370.
  • Joslyn G, Brush G, Robertson M, Smith TL, Kalmijn J, Schuckit M, White RL (2008) Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans. Proc Natl Acad Sci U S A 105(51):2036820373.
  • Kaminski RM, Banerjee M, Rogawski MA (2004) Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology 46(8):10971104.
  • Kanehisa M, Goto S (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):2730.
  • Kleinjan DA, Van Heyningen V (2005) Long-range control of gene expression: emerging mechanisms and disruption in disease. Am J Hum Genet 76(1):832.
  • Kranzler HR, Gelernter J, Anton RF, Arias AJ, Herman A, Zhao H, Burian L, Covault J (2009) Association of markers in the 3′ region of the GluR5 kainate receptor subunit gene to alcohol dependence. Alcohol Clin Exp Res 33(5):925930.
  • Krystal JH, Petrakis IL, Krupitsky E, Schutz C, Trevisan L, D’Souza DC (2003) NMDA receptor antagonism and the ethanol intoxication signal: from alcoholism risk to pharmacotherapy. Ann N Y Acad Sci 1003:176184.
  • Li TK (2000) Pharmacogenetics of responses to alcohol and genes that influence alcohol drinking. J Stud Alcohol 61(1):512.
  • Lovinger DM, White G, Weight FF (1989) Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243(4899):17211724.
  • Lovinger DM, White G, Weight FF (1990) NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat. J Neurosci 10(4):13721379.
  • Madden PA, Heath AC, Starmer GA, Whitfield JB, Martin NG (1995) Alcohol sensitivity and smoking history in men and women. Alcohol Clin Exp Res 19(5):11111120.
  • Martin NG, Oakeshott JG, Gibson JB, Wilks AV, Starmer GA, Whitfield JB (1981) Prodromus to a twin study of sensitivity to intoxication and alcohol metabolism. Aust N Z J Med 11(2):140143.
  • McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP, Hirschhorn JN (2008) Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 9(5):356369.
  • McCarthy MI, Hirschhorn JN (2008) Genome-wide association studies: potential next steps on a genetic journey. Hum Mol Genet 17(R2):R156R165.
  • Michaelis EK (1998) Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog Neurobiol 54(4):369415.
  • Moore MS, DeZazzo J, Luk AY, Tully T, Singh CM, Heberlein U (1998) Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93(6):9971007.
  • Morris RG, Anderson E, Lynch GS, Baudry M (1986) Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319(6056):774776.
  • Nevo I, Hamon M (1995) Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism. Neurochem Int 26(4):305336.
  • Petrakis IL, Limoncelli D, Gueorguieva R, Jatlow P, Boutros NN, Trevisan L, Gelernter J, Krystal JH (2004) Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism. Am J Psychiatry 161(10):17761782.
  • Pollock VE (1992) Meta-analysis of subjective sensitivity to alcohol in sons of alcoholics. Am J Psychiatry 149(11):15341538.
  • RDevelopmentCoreTeam (2008) R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. Available at: http://www.R-project.org.
  • Reiner A, Yekutieli D, Benjamini Y (2003) Identifying differentially expressed genes using false discovery rate controlling procedures. Bioinformatics 19(3):368375.
  • Ren H, Salous AK, Paul JM, Lipsky RH, Peoples RW (2007) Mutations at F637 in the NMDA receptor NR2A subunit M3 domain influence agonist potency, ion channel gating and alcohol action. Br J Pharmacol 151(6):749757.
  • Schuckit MA, Gold EO (1988) A simultaneous evaluation of multiple markers of ethanol/placebo challenges in sons of alcoholics and controls. Arch Gen Psychiatry 45(3):211216.
  • Schuckit MA, Smith TL (1996) An 8-year follow-up of 450 sons of alcoholic and control subjects. Arch Gen Psychiatry 53(3):202210.
  • Schuckit MA, Smith TL (2000) The relationships of a family history of alcohol dependence, a low level of response to alcohol and six domains of life functioning to the development of alcohol use disorders. J Stud Alcohol 61(6):827835.
  • Schuckit MA, Smith TL, Danko GP, Pierson J, Hesselbrock V, Bucholz KK, Kramer J, Kuperman S, Dietiker C, Brandon R, Chan G (2007) The ability of the Self-Rating of the Effects of Alcohol (SRE) Scale to predict alcohol-related outcomes five years later. J Stud Alcohol Drugs 68(3):371378.
  • Schuckit MA, Smith TL, Kalmijn J, Tsuang J, Hesselbrock V, Bucholz K (2000) Response to alcohol in daughters of alcoholics: a pilot study and a comparison with sons of alcoholics. Alcohol Alcohol 35(3):242248.
  • Schuckit MA, Tipp JE, Smith TL, Wiesbeck GA, Kalmijn J (1997) The relationship between Self-Rating of the Effects of alcohol and alcohol challenge results in ninety-eight young men. J Stud Alcohol 58(4):397404.
  • Schuckit MA, Tsuang JW, Anthenelli RM, Tipp JE, Nurnberger JI Jr (1996) Alcohol challenges in young men from alcoholic pedigrees and control families: a report from the COGA project. J Stud Alcohol 57(4):368377.
  • Schuckit MA, Wilhelmsen K, Smith TL, Feiler HS, Lind P, Lange LA, Kalmijn J (2005) Autosomal linkage analysis for the level of response to alcohol. Alcohol Clin Exp Res 29(11):19761982.
  • Storey JD, Tibshirani R (2003) Statistical significance for genome wide studies. Proc Natl Acad Sci U S A 100(16):94409445.
  • Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102(43):1554515550.
  • Tsai G, Gastfriend DR, Coyle JT (1995) The glutamatergic basis of human alcoholism. Am J Psychiatry 152(3):332340.
  • Uhl GR, Drgon T, Johnson C, Fatusin OO, Liu QR, Contoreggi C, Li CY, Buck K, Crabbe J (2008) “Higher order” addiction molecular genetics: convergent data from genome-wide association in humans and mice. Biochem Pharmacol 75(1):98111.
  • Ungless MA, Whistler JL, Malenka RC, Bonci A (2001) Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature 411(6837):583587.
  • Venables WN, Ripley BD (2002) Modern Applied Statistics with S. Springer, New York.
  • Wang WY, Barratt BJ, Clayton DG, Todd JA (2005) Genome-wide association studies: theoretical and practical concerns. Nat Rev Genet 6(2):109118.
  • Wang JC, Grucza R, Cruchaga C, Hinrichs AL, Bertelsen S, Budde JP, Fox L, Goldstein E, Reyes O, Saccone N, Saccone S, Xuei X, Bucholz K, Kuperman S, Nurnberger J, Jr., Rice JP, Schuckit M, Tischfield J, Hesselbrock V, Porjesz B, Edenberg HJ, Bierut LJ, Goate AM (2008) Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. Mol Psychiatry 14(5):501510.
  • Wang K, Li M, Bucan M (2007) Pathway-based approaches for analysis of genomewide association studies. Am J Hum Genet 81(6):12781283.
  • Wilhelmsen KC, Schuckit M, Smith TL, Lee JV, Segall SK, Feiler HS, Kalmijn J (2003) The search for genes related to a low-level response to alcohol determined by alcohol challenges. Alcohol Clin Exp Res 27(7):10411047.
  • Yaka R, Tang KC, Camarini R, Janak PH, Ron D (2003) Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward. Alcohol Clin Exp Res 27(11):17361742.