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Influence of Dissolved Oxygen Concentration on the Pharmacokinetics of Alcohol in Humans
Article first published online: 1 MAR 2010
DOI: 10.1111/j.1530-0277.2010.01155.x
Copyright © 2010 by the Research Society on Alcoholism
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How to Cite
Baek, I.-h., Lee, B.-y. and Kwon, K.-i. (2010), Influence of Dissolved Oxygen Concentration on the Pharmacokinetics of Alcohol in Humans. Alcoholism: Clinical and Experimental Research, 34: 834–839. doi: 10.1111/j.1530-0277.2010.01155.x
Publication History
- Issue published online: 23 APR 2010
- Article first published online: 1 MAR 2010
- Received for publication July 7, 2009; accepted December 20, 2008.
- Abstract
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Keywords:
- Alcohol;
- Dissolved Oxygen Concentration;
- Pharmacokinetics
Background: Ethanol oxidation by the microsomal ethanol oxidizing system requires oxygen for alcohol metabolism, and a higher oxygen uptake increases the rate of ethanol oxidation. We investigated the effect of dissolved oxygen on the pharmacokinetics of alcohol in healthy humans (n = 49). The concentrations of dissolved oxygen were 8, 20, and 25 ppm in alcoholic drinks of 240 and 360 ml (19.5% v/v).
Methods: Blood alcohol concentrations (BACs) were determined by converting breath alcohol concentrations. Breath samples were collected every 30 min when the BAC was higher than 0.015%, 20 min at BAC ≤0.015%, 10 min at BAC ≤0.010%, and 5 min at BAC ≤0.006%.
Results: The high dissolved oxygen groups (20, 25 ppm) descended to 0.000% and 0.050% BAC faster than the normal dissolved oxygen groups (8 ppm; p < 0.05). In analyzing pharmacokinetic parameters, AUCinf and Kel of the high oxygen groups were lower than in the normal oxygen group, while Cmax and Tmax were not significantly affected. In a Monte Carlo simulation, the lognormal distribution of mean values of AUCinf and t1/2 was expected to be reduced in the high oxygen group compared to the normal oxygen group.
Conclusions: In conclusion, elevated dissolved oxygen concentrations in alcoholic drinks accelerate the metabolism and elimination of alcohol. Thus, enhanced dissolved oxygen concentrations in alcohol may have a role to play in reducing alcohol-related side effects and accidents.