The subject of this mini-review has been presented in a symposium held at the Scientific Meeting of the Research Society on Alcoholism (RSA), June 20 to 24, 2009 (San Diego, CA). Organizer and Chair of the symposium was Lorenzo Leggio. Co-chairs were Giovanni Addolorato and Robert Swift. Introducer was Lorenzo Leggio. Speakers were Alexei Kampov-Polevoy, Andrea Cippitelli, Elisabet Jerlhag, and Lorenzo Leggio. Discussant was Robert Swift.
Role of Feeding-Related Pathways in Alcohol Dependence: A Focus on Sweet Preference, NPY, and Ghrelin
Article first published online: 8 NOV 2010
Copyright © 2010 by the Research Society on Alcoholism
Alcoholism: Clinical and Experimental Research
Volume 35, Issue 2, pages 194–202, February 2011
How to Cite
Leggio, L., Addolorato, G., Cippitelli, A., Jerlhag, E., Kampov-Polevoy, A. B. and Swift, R. M. (2011), Role of Feeding-Related Pathways in Alcohol Dependence: A Focus on Sweet Preference, NPY, and Ghrelin. Alcoholism: Clinical and Experimental Research, 35: 194–202. doi: 10.1111/j.1530-0277.2010.01334.x
- Issue published online: 24 JAN 2011
- Article first published online: 8 NOV 2010
- Received for publication February 2, 2010; accepted July 23, 2010.
- Alcohol Dependence;
- Alcohol Craving;
- Feeding-Related Pathways;
- Sweet Preference;
- Feeding-Related Peptides;
- Neuropeptide Y;
Converging research evidence suggests that alcohol and food-seeking behaviors share common neural pathways. There is preclinical and clinical evidence linking the consumption of sweets to alcohol intake in both animals and humans. In addition, a growing body of animal and human literature suggests the involvement of “feeding-related” peptides in alcohol-seeking behavior. In particular, both central and peripheral appetitive peptides have shown a possible role in alcohol dependence. The present mini-review will summarize the literature on the link between sweet preference and alcohol dependence, and on the role of feeding-related peptides in alcohol dependence. Specifically, in an attempt to narrow the field, the present mini-review will focus on 2 specific pathways, the central neuropeptide Y and the peripheral gut peptide ghrelin. Although more research is needed, data available suggest that studying feeding-related pathways in alcohol dependence may have theoretic, biologic, diagnostic, and therapeutic implications.