Dendritic Cells in Alcoholic Liver Injury and Fibrosis
Article first published online: 1 FEB 2011
Copyright © 2011 by the Research Society on Alcoholism
Alcoholism: Clinical and Experimental Research
Volume 35, Issue 5, pages 776–781, May 2011
How to Cite
Aloman, C., Friedman, S. L. and Merad, M. (2011), Dendritic Cells in Alcoholic Liver Injury and Fibrosis. Alcoholism: Clinical and Experimental Research, 35: 776–781. doi: 10.1111/j.1530-0277.2010.01397.x
- Issue published online: 26 APR 2011
- Article first published online: 1 FEB 2011
- Received for publication March 18, 2010; accepted September 9, 2010.
- Dendritic Cells;
- Liver Fibrosis;
- Immune Responses;
- Acute Alcoholic Liver Injury
Alcohol consumption impairs the development of innate and adaptive immune responses, however the exact mechanism by which alcohol leads to immune defects remains to be established. Dendritic cells (DCs) form a heterogeneous population of hematopoietic cells that are present in all tissues including the liver. DC are initially described playing a key role in the induction of innate and adaptive immune response against specific antigens. In our presentation, we discussed few new aspects of DC development, critical assessment of DC in non-lymphoid organs and the impact of alcohol consumption on DC function. Understanding the mechanism by which DC modulate liver function after alcohol consumption may help uncover novel therapeutic strategies for the treatment of these conditions.