Acetaldehyde Burst Protection of ADH1B*2 Against Alcoholism: An Additional Hormesis Protection Against Esophageal Cancers Following Alcohol Consumption?

  1. Yedy Israel,
  2. Mario Rivera-Meza,
  3. María Elena Quintanilla,
  4. Amalia Sapag,
  5. Lutske Tampier

Article first published online: 1 FEB 2011

DOI: 10.1111/j.1530-0277.2010.01403.x

Issue

Alcoholism: Clinical and Experimental Research

Alcoholism: Clinical and Experimental Research

Volume 35, Issue 5, pages 806–810, May 2011

Additional Information

How to Cite

Israel, Y., Rivera-Meza, M., Quintanilla, M. E., Sapag, A. and Tampier, L. (2011), Acetaldehyde Burst Protection of ADH1B*2 Against Alcoholism: An Additional Hormesis Protection Against Esophageal Cancers Following Alcohol Consumption?. Alcoholism: Clinical and Experimental Research, 35: 806–810. doi: 10.1111/j.1530-0277.2010.01403.x

Author Information

  1. From the Department of Pharmacological and Toxicological Chemistry (YI, MRM, AS), Faculty of Chemical and Pharmaceutical Sciences, Department of Molecular and Clinical Pharmacology (YI, MEQ, LT), Institute of Biomedical Sciences, Faculty of Medicine, 3Millennium Institute for Cell Dynamics and Biotechnology (YI), University of Chile, Santiago, Chile, and Department of Pathology (YI), Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

*Reprint requests: Yedy Israel, PhD, Laboratory of Gene Therapy, Universidad de Chile, Sergio Livingstone (Ex Olivos) 1007, Independencia, Santiago, Chile; Tel.: +56 2 978-2943; Fax: + 56 2 737-7291; E-mail: yisrael@uchile.cl

Publication History

  1. Issue published online: 26 APR 2011
  2. Article first published online: 1 FEB 2011
  3. Received for publication March 16, 2010; accepted July 15, 2010.

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Keywords:

  • Polymorphism;
  • Alcohol;
  • Dehydrogenase;
  • Acetaldehyde;
  • Alcoholism;
  • Cancer

This account of recent work presented at the 4th International Symposium on Alcohol Pancreatitis and Cirrhosis reports animal studies aimed at determining the role of the “acetaldehyde burst,” generated shortly upon ethanol intake, as the mechanism of protection against alcoholism conferred by the ADH1B*2 polymorphism. Literature studies discussed suggest an additional role of the acetaldehyde burst on the paradoxical (hormesis) protection of the ADH1B*2 polymorphism against esophageal cancers in alcoholics.

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