Alcoholic Liver Disease and Malnutrition
Article first published online: 1 FEB 2011
Copyright © 2011 by the Research Society on Alcoholism
Alcoholism: Clinical and Experimental Research
Volume 35, Issue 5, pages 815–820, May 2011
How to Cite
McClain, C. J., Barve, S. S., Barve, A. and Marsano, L. (2011), Alcoholic Liver Disease and Malnutrition. Alcoholism: Clinical and Experimental Research, 35: 815–820. doi: 10.1111/j.1530-0277.2010.01405.x
- Issue published online: 26 APR 2011
- Article first published online: 1 FEB 2011
- Received for publication March 26, 2010; accepted August 30, 2010.
Malnutrition, both protein energy malnutrition (PEM) and deficiencies in individual nutrients, is a frequent complication of alcoholic liver disease (ALD). Severity of malnutrition correlates with severity of ALD. Malnutrition also occurs in patients with cirrhosis due to etiologies other than alcohol. The mechanisms for malnutrition are multifactorial, and malnutrition frequently worsens in the hospital due to fasting for procedures and metabolic complications of liver disease, such as hepatic encephalopathy. Aggressive nutritional support is indicated in inpatients with ALD, and patients often need to be fed through an enteral feeding tube to achieve protein and calorie goals. Enteral nutritional support clearly improves nutrition status and may improve clinical outcome. Moreover, late-night snacks in outpatient cirrhotics improve nutritional status and lean body mass. Thus, with no FDA-approved therapy for ALD, careful nutritional intervention should be considered as frontline therapy.