Molecular Pathogenesis of Hepatocellular Carcinoma
Article first published online: 8 FEB 2011
Copyright © 2011 by the Research Society on Alcoholism
Alcoholism: Clinical and Experimental Research
Volume 35, Issue 5, pages 821–825, May 2011
How to Cite
Cornellà, H., Alsinet, C. and Villanueva, A. (2011), Molecular Pathogenesis of Hepatocellular Carcinoma. Alcoholism: Clinical and Experimental Research, 35: 821–825. doi: 10.1111/j.1530-0277.2010.01406.x
- Issue published online: 26 APR 2011
- Article first published online: 8 FEB 2011
- Received for publication March 22, 2010; accepted May 25, 2010.
- Hepatocellular Carcinoma;
- Signaling Pathways;
- Molecular Targeted Therapies;
- Prognosis Prediction
Hepatocellular carcinoma (HCC) is one of the major causes of death among cirrhotic patients, being viral hepatitis and alcohol abuse, the main risk factors for its development. The introduction of highly sophisticated genomic technologies has spurred extensive research on the molecular pathogenesis of this devastating disease. Several signaling cascades have been consistently found dysregulated in HCC (e.g., WNT-β-catenin, PI3K/AKT/MTOR, RAS/MAPK, IGF, HGF/MET, VEGF, EGFR, and PDGF). In addition, there have been numerous molecular classifications proposed for this disease, what provides an additional hint about its genomic complexity. The importance of knowing the molecular drivers of HCC is underscored by the positive results of a molecular targeted agent, sorafenib, able to improve survival in patients with advanced disease. This review will briefly outline key concepts in alcohol-related hepatocarcinogenesis, and provide some insight regarding current trends in translating HCC genomics into clinical management of the disease.