Alcohol Has a Dose-Related Effect on Parasympathetic Nerve Activity During Sleep
Version of Record online: 16 AUG 2011
Copyright © 2011 by the Research Society on Alcoholism
Alcoholism: Clinical and Experimental Research
Volume 35, Issue 11, pages 2093–2100, November 2011
How to Cite
Sagawa, Y., Kondo, H., Matsubuchi, N., Takemura, T., Kanayama, H., Kaneko, Y., Kanbayashi, T., Hishikawa, Y. and Shimizu, T. (2011), Alcohol Has a Dose-Related Effect on Parasympathetic Nerve Activity During Sleep. Alcoholism: Clinical and Experimental Research, 35: 2093–2100. doi: 10.1111/j.1530-0277.2011.01558.x
- Issue online: 1 NOV 2011
- Version of Record online: 16 AUG 2011
- Received for publication December 9, 2010; accepted March 20, 2011.
- Autonomic Nerve Activity;
- Heart Rate Variability
Background: The aim of this study was to identify the acute effects of ethanol on the relationship between sleep and heart rate variability (HRV) during sleep.
Methods: Ten healthy male university students were enrolled in this study. An alcoholic beverage was given to each subject at a dosage of 0 (control), 0.5 (low dose: LD), or 1.0 g (high dose: HD) of pure ethanol/kg of body weight. All experiments were performed at 3-week intervals. On the day of the experiment, a Holter electrocardiogram was attached to the subject for a 24-hour period, and the subject was instructed to drink the above-described dosage of alcoholic beverage 100 minutes before going to bed; polysomnography was then performed for 8 hours. Power spectral analysis of the HRV was performed using the maximum entropy method, and the low- (LF: 0.04 to 0.15 Hz) and high-frequency (HF: 0.15 to 0.4 Hz) components along with LF/HF ratio were calculated.
Results: As alcohol consumption increased, the heart rate increased and the spectral power of HRV measured at each frequency range decreased. Higher doses of ethanol also increased the LF/HF ratio compared with the measured ratio of the control group.
Conclusions: Acute ethanol intake inhibits parasympathetic nerve activity and results in predominance of sympathetic nerve activity during sleep, in a dosage-dependent manner. The results of this study suggest that ethanol interferes with the restorative functions of sleep.