Behavior, Treatment and Prevention
Possible Association Between OPRM1 Genetic Variance at the 118 Locus and Alcohol Dependence in a Large Treatment Sample: Relationship to Alcohol Dependence Symptoms
Article first published online: 6 FEB 2012
Copyright © 2012 by the Research Society on Alcoholism
Alcoholism: Clinical and Experimental Research
Volume 36, Issue 7, pages 1230–1236, July 2012
How to Cite
Koller, G., Zill, P., Rujescu, D., Ridinger, M., Pogarell, O., Fehr, C., Wodarz, N., Bondy, B., Soyka, M. and Preuss, U. W. (2012), Possible Association Between OPRM1 Genetic Variance at the 118 Locus and Alcohol Dependence in a Large Treatment Sample: Relationship to Alcohol Dependence Symptoms. Alcoholism: Clinical and Experimental Research, 36: 1230–1236. doi: 10.1111/j.1530-0277.2011.01714.x
- Issue published online: 10 JUL 2012
- Article first published online: 6 FEB 2012
- Manuscript Accepted: 26 OCT 2011
- Manuscript Received: 22 MAR 2011
- Opioid Receptor;
Several lines of evidence from previous research indicate that opioid receptors play an important role in ethanol reinforcement and alcohol dependence (AD) risk. Conflicting results were reported on the role of the mu-opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism.
We investigated a total number of 1,845 alcohol-dependent subjects recruited from inpatient facilities in Germany and 1,863 controls for the mu-opioid receptor (OPRM1) polymorphism using chi-square statistics.
An association between the OPRM variant and AD was detected (p = 0.022), in recessive (AA vs. GA/GG) and co-dominant (AA vs. GA) models of inheritance. An association between the OPRM variant and the DSM-IV criterion “efforts to cut down or could not” (p = 0.047) was found, but this did not remain significant after the correction for multiple testing.
The results indicate that this functional OPRM variant is associated with risk of AD and these findings apply to more severe AD, although the association is only nominally significant.