SEARCH

SEARCH BY CITATION

FilenameFormatSizeDescription
acer1829-sup-0001-FigS1-S5.docWord document3193KFig. S1. Blood alcohol concentration results. Total association of 950 SNPs spanning 14 candidate genes with a time course of 6 blood (LP1-LP6) alcohol concentration levels following ingestion of a weight-related dose of EtOH. Fig. S2. Breath alcohol concentration results. Total association of 950 SNPs spanning 14 candidate genes with a time course of 10 breath (RP01-RP10) alcohol concentration levels following ingestion of a weight-related dose of EtOH. Fig. S3. Blood and breath summary measure results. Total association of 950 SNPs spanning 14 candidate genes with the rate of alcohol absorption, rate of alcohol elimination and peak alcohol concentration in the blood (BLAP, BLEP and PKLP respectively) and breath (BRAP, BREP, PKRP). Fig. S4. Multivariate total association of SNPs spanning 14 candidate genes with general blood alcohol metabolism (all times, LP1-LP10), early (LP1-LP3) and late (LP4-LP6) blood alcohol concentration levels, general breath alcohol metabolism (all times, RP01-RP10) and early (RP01-RP05) and late (RP06-RP10) breath alcohol concentration levels following ingestion of a weight-related dose of EtOH. Fig. S5. Sequenom MassARRAY (a) cluster plot for the CYP2E1 promoter SNP rs4838767 assay, and (b) spectrums for the heterozygote A/C and homozygote A/A genotypes.
acer1829-sup-0002-TableS1-S7.xlsapplication/msexcel1609KTable. S1. Summary of 818 SNPs imputed using genotype data from genome wide association studies. Table. S2. Genotype comparison of 118 SNPs genotyped in-house using the Sequenom MassARRAY platform with imputed genotypes from GWAS data. Table. S3. QTDT total association for all SNPS and all blood and breath phenotypes. Table. S4. QTDT population stratification results for all SNPs and all blood and breath phenotypes. Table. S5. Correlation matrix for all breath and blood phenotypes tested. Table S6. MQFAM multivariate total association with all SNPs. Table S7. Empirical p-values for association with rs4838767 at each phenotype following genotype simulation analysis in MERLIN.

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.