Fetal Brain Function in Response to Maternal Alcohol Consumption: Early Evidence of Damage
Article first published online: 14 SEP 2012
Copyright © 2012 by the Research Society on Alcoholism
Alcoholism: Clinical and Experimental Research
Volume 36, Issue 12, pages 2168–2175, December 2012
How to Cite
Hepper, P. G., Dornan, J. C. and Lynch, C. (2012), Fetal Brain Function in Response to Maternal Alcohol Consumption: Early Evidence of Damage. Alcoholism: Clinical and Experimental Research, 36: 2168–2175. doi: 10.1111/j.1530-0277.2012.01832.x
- Issue published online: 11 DEC 2012
- Article first published online: 14 SEP 2012
- Manuscript Accepted: 22 MAR 2012
- Manuscript Received: 16 DEC 2011
- R&D Office
- Department of Health and Social Services and Public Safety
- NI. Grant Number: 5 U24 AA014828
- National Institute on Alcohol and Alcohol Abuse (NIAAA)
- Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD)
- Fetal Alcohol Spectrum Disorders;
- Binge Drinking;
- Brain Function;
- Neurobehavioral Development
Studies of the adverse neurobehavioral effects of maternal alcohol consumption on the fetus have been largely confined to the postnatal period, after exposure to alcohol has finished. This study explored the brain function of the fetus, at the time of exposure to alcohol, to examine its effect on information processing and stability of performance.
Five groups of fetuses, defined by maternal alcohol consumption patterns, were examined: control (no alcohol); moderate (5 to 10 units/wk either drunk evenly across the week or as a binge, in 2 to 3 days); heavy (20+ units/wk drunk evenly or as a binge). Fetal habituation performance was examined on 3 occasions, separated by 7 days, beginning at 35 weeks of gestation. The number of trials required to habituate on each test session and the difference in performance across test sessions were recorded.
Fetuses exposed to heavy binge drinking required significantly more trials to habituate and exhibited a greater variability in performance across all test sessions than the other groups. Maternal drinking, either heavily but evenly or moderately as a binge, resulted in poorer habituation, and moderate binge drinking resulted in greater variability compared with no, or even, drinking.
Decreased information processing, reflected by poorer habituation, and increased variability in performance may reflect the initial manifestations of structural damage caused by alcohol to the brain. These results will lead to a greater understanding of the effects of alcohol on the fetus's brain, enable the antenatal identification of fetal alcohol spectrum disorders, and lead to the early implementation of better management strategies.