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Original Article

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Role of Adrenal Glucocorticoid Signaling in Prefrontal Cortex Gene Expression and Acute Behavioral Responses to Ethanol

  1. Blair N. Costin1,2,
  2. Aaron R. Wolen1,3,
  3. Sylvia Fitting2,
  4. Keith L. Shelton2,
  5. Michael F. Miles1,2,3,4,*

Article first published online: 4 JUN 2012

DOI: 10.1111/j.1530-0277.2012.01841.x

Issue

Alcoholism: Clinical and Experimental Research

Alcoholism: Clinical and Experimental Research

Volume 37, Issue 1, pages 57–66, January 2013

Additional Information

How to Cite

Costin, B. N., Wolen, A. R., Fitting, S., Shelton, K. L. and Miles, M. F. (2013), Role of Adrenal Glucocorticoid Signaling in Prefrontal Cortex Gene Expression and Acute Behavioral Responses to Ethanol. Alcoholism: Clinical and Experimental Research, 37: 57–66. doi: 10.1111/j.1530-0277.2012.01841.x

Author Information

  1. 1

    VCU Alcohol Research Center, Virginia Commonwealth University, Richmond, Virginia

  2. 2

    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia

  3. 3

    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia

  4. 4

    Department of Neurology, Virginia Commonwealth University, Richmond, Virginia

* Reprint requests: Michael F. Miles, MD, PhD, Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980599, Richmond, VA 23298; Tel.: 804-827-4054; Fax: 804-828-6432; E-mail: mfmiles@vcu.edu

Publication History

  1. Issue published online: 4 JAN 2013
  2. Article first published online: 4 JUN 2012
  3. Manuscript Accepted: 18 MAR 2012
  4. Manuscript Received: 5 OCT 2011

Funded by

  • NIAAA. Grant Numbers: R01AA014717, U01AA016667, P20AA017828, RO1DA020553, 1 F31 AA 020141-01

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FilenameFormatSizeDescription
acer1841-sup-0001-FigS1.pdfapplication/PDF170K Fig. S1. ADX animals showed a lower peak BEC and unaltered rate of clearance following 2 g/kg ethanol (n = 9 to 10/group; 78 mice total).
acer1841-sup-0002-FigS2.pdfapplication/PDF165K Fig. S2. There were no differences in BEC between D2 animals pretreated with 35 mg/kg RU-486 versus those pre-treated with VEH following 10 minutes, 1 hour, 2 and 4 hours following 2 g/kg ethanol administration (n = 5 to 6/group; 48 mice total).
acer1841-sup-0003-FigS3.pdfapplication/PDF173K Fig. S3. A corticosterone (cort.) time course was performed to measure HPA axis activation following 2 g/kg ethanol administration (n = 5 to 6/group; 52 mice total).
acer1841-sup-0004-TableS1.pdfapplication/PDF181K Table S1. Microarray analysis: Probe sets with significant basal differences (q-value ≤ 0.05) between SHAM and ADX mice.

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