The subject of this mini-review has been presented in a symposium held at the Research Society on Alcoholism (RSA), June 25 to June 29, 2011 (Atlanta, Georgia). Organizers and Chairs of the symposium were Richard Olsen and Daryl Davies. Introducer was Richard Olsen. Speakers were Richard Olsen, Deb Finn, Segev Barak, and Daryl Davies. Discussant was Dorit Ron.
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Critical Review
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Recent Advances in the Discovery and Preclinical Testing of Novel Compounds for the Prevention and/or Treatment of Alcohol Use Disorders
Article first published online: 4 JUN 2012
DOI: 10.1111/j.1530-0277.2012.01846.x
Copyright © 2012 by the Research Society on Alcoholism
Additional Information
How to Cite
Davies, D. L., Bortolato, M., Finn, D. A., Ramaker, M. J., Barak, S., Ron, D., Liang, J. and Olsen, R. W. (2013), Recent Advances in the Discovery and Preclinical Testing of Novel Compounds for the Prevention and/or Treatment of Alcohol Use Disorders. Alcoholism: Clinical and Experimental Research, 37: 8–15. doi: 10.1111/j.1530-0277.2012.01846.x
Publication History
- Issue published online: 4 JAN 2013
- Article first published online: 4 JUN 2012
- Manuscript Accepted: 26 MAR 2012
- Manuscript Received: 17 FEB 2012
Funded by
- NIAAA. Grant Number: AA007680
- RWO. Grant Numbers: AA017991, AA013922
- Integrative Neurosciences Initiative on Alcoholism. Grant Numbers: AA013517, AA012439, AA016981
- Department of Veterans Affairs. Grant Number: RO1 AA014366
- State of California for Medical Research on Alcohol
- Substance Abuse through the University of California San Francisco. Grant Number: T32 AA07468
- Abstract
- Article
- References
- Cited By
Keywords:
- GABAA Receptors;
- Purinergic Receptors;
- Glial Cell Line-Derived Neurotrophic Factor;
- Dihydromyricetin;
- Ganaxolone;
- Ivermectin
Abstract
Alcohol abuse and dependence have a staggering socioeconomic impact, yet current therapeutic strategies are largely inadequate to treat these disorders. Thus, the development of new strategies that can effectively prevent alcohol use disorders (AUDs) is of paramount importance. Currently approved medications attempt to deter alcohol intake by blocking ethanol metabolism or by targeting the neurochemical systems downstream of the cascades leading to craving and dependence. Unfortunately, these medications have provided only limited success as indicated by the continued high rates of alcohol abuse and alcoholism. The lack of currently available effective treatment strategies is highlighted by the urgent call by the NIAAA to find new and paradigm-changing therapeutics to either prevent or treat alcohol-related problems. This mini-review highlights recent findings from 4 laboratories with a focus on compounds that have the potential to be novel therapeutic agents that can be developed for the prevention and/or treatment of AUDs.