Resting-State Synchrony in Long-Term Abstinent Alcoholics
Article first published online: 22 JUN 2012
Copyright © 2012 by the Research Society on Alcoholism
Alcoholism: Clinical and Experimental Research
Volume 37, Issue 1, pages 75–85, January 2013
How to Cite
Camchong, J., Stenger, A. and Fein, G. (2013), Resting-State Synchrony in Long-Term Abstinent Alcoholics. Alcoholism: Clinical and Experimental Research, 37: 75–85. doi: 10.1111/j.1530-0277.2012.01859.x
- Issue published online: 4 JAN 2013
- Article first published online: 22 JUN 2012
- Manuscript Accepted: 2 APR 2012
- Manuscript Received: 21 NOV 2011
- National Institutes for Health. Grant Numbers: #5R01AA016944, #5R01AA013659
- Resting State;
- Anterior Cingulate
Alcohol dependence is a disorder with an impulsive and compulsive “drive” toward alcohol consumption and an inability to inhibit alcohol consumption. Neuroimaging studies suggest that these behavioral components correspond to an increased involvement of regions that mediate appetitive drive and reduced involvement of regions that mediate executive control within top-down networks. Little is known, however, about whether these characteristics are present after long periods of abstinence.
Resting-state functional magnetic resonance imaging data were collected to examine resting-state synchrony (RSS) differences between 23 long-term abstinent alcoholics (LTAA; 8 women, age: M = 48.46, SD = 7.10), and 23 nonsubstance abusing controls (NSAC; 8 women, age: M = 47.99, SD = 6.70). Using seed-based measures, we examined RSS with the nucleus accumbens (NAcc) and the subgenual anterior cingulate cortex (sgACC). All participants were assessed with the intra/extradimensional set shift task outside of the scanner to explore the relationship between RSS and cognitive flexibility.
Compared to NSAC, LTAA showed (i) decreased synchrony of limbic reward regions (e.g., caudate and thalamus) with both the anterior cingulate cortex seed and the NAcc seed and (ii) increased synchrony of executive control regions (e.g., dorsolateral prefrontal cortex) with both the NAcc seed and the sgACC seed. RSS differences were significantly correlated with task performance.
The results are consistent with an interpretation of an ongoing compensatory mechanism in LTAA evident during rest, in which decision-making networks show reduced synchrony with appetitive drive regions and increased synchrony with inhibitory control regions. In addition, RSS differences were associated with cognitive flexibility. These resting-state findings indicate an adaptive mechanism present in long-term abstinence that may facilitate the behavioral control required to maintain abstinence.