A Meta-Analysis on the Impact of Alcohol Dependence on Short-Term Resting-State Heart Rate Variability: Implications for Cardiovascular Risk
Article first published online: 26 JUL 2012
Copyright © 2012 by the Research Society on Alcoholism
Alcoholism: Clinical and Experimental Research
Volume 37, Issue Supplement s1, pages E23–E29, January 2013
How to Cite
Quintana, D. S., McGregor, I. S., Guastella, A. J., Malhi, G. S. and Kemp, A. H. (2013), A Meta-Analysis on the Impact of Alcohol Dependence on Short-Term Resting-State Heart Rate Variability: Implications for Cardiovascular Risk. Alcoholism: Clinical and Experimental Research, 37: E23–E29. doi: 10.1111/j.1530-0277.2012.01913.x
- Issue published online: 15 JAN 2013
- Article first published online: 26 JUL 2012
- Manuscript Accepted: 4 JUN 2012
- Manuscript Received: 31 JAN 2012
- Australian Rotary Health. Grant Number: 571101
- Australian Research Council. Grant Number: 571101
- National Health and Medical Research Council. Grant Numbers: 571101, 0771426, 512523, 510135
- Alcohol Dependence;
- Heart Rate Variability;
- Cardiovascular Disease
Alcohol dependence is associated with an increased likelihood of cardiac events. Reductions in heart rate variability (HRV) may be one mechanism linking dependence with these events. HRV may also be related to poor social functioning and the lack of impulse control commonly observed in alcohol-dependent individuals. However, prior studies on the impact of alcohol dependence on HRV have reported contradictory findings highlighting the need for a meta-analysis.
Studies comparing short-term HRV in alcohol-dependent populations and healthy controls who were nondependent were considered for meta-analysis. Only studies reporting findings from participants without cardiovascular disease were included in the analysis.
Meta-analyses were based on 6 articles that fulfilled inclusion criteria, comprising a total of 177 alcohol-dependent participants and 216 nondependent participants. Alcohol-dependent participants displayed reduced HRV (Hedges' g = −0.6, p > 0.001) in comparison with nondependent participants. No differences were observed between the summary effect sizes obtained from different HRV domains (Q = 1.19, p = 0.55).
Alcohol dependence is associated with reduced HRV, an effect associated with a medium effect size. Findings highlight the importance of monitoring alcohol-dependent patients for cardiac disease and emphasize the need for cardiovascular risk reduction strategies in these patients.