A Role of Genomic Copy Number Variation in the Complex Behavioral Phenotype of Alcohol Dependence: A Commentary

Authors

  • Alexander E. Urban

    Corresponding author
    • Department of Psychiatry and Behavioral Sciences, Department of Genetics (AEU), Stanford University School of Medicine, Palo Alto, California
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Reprint requests: Alexander E. Urban, PhD, Department of Psychiatry and Behavioral Sciences, Department of Genetics, Stanford University School of Medicine, 1050A Arastradero Road, Room A233A, Palo Alto, CA 94304-5742; Tel.: 650-736-9528; Fax: 650-725-4913; E-mail: aeurban@stanford.edu

Abstract

In their paper “Copy number variations in 6q14.1 and 5q13.2 are associated with alcohol dependence” Lin and colleagues report on the association between alcohol dependence and 2 duplication CNVs in the genome sequence, one containing 8 genes within its boundaries and another that contains no genes. In this commentary, I point out some of the opportunities and challenges that arise from such a finding.

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