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Array-Based Profiling of DNA Methylation Changes Associated with Alcohol Dependence

  1. Huiping Zhang1,2,*,
  2. Aryeh I. Herman1,2,
  3. Henry R. Kranzler3,
  4. Raymond F. Anton4,
  5. Hongyu Zhao5,6,
  6. Wei Zheng7,
  7. Joel Gelernter1,2,5,8

Article first published online: 24 AUG 2012

DOI: 10.1111/j.1530-0277.2012.01928.x

Issue

Alcoholism: Clinical and Experimental Research

Alcoholism: Clinical and Experimental Research

Volume 37, Issue Supplement s1, pages E108–E115, January 2013

Additional Information

How to Cite

Zhang, H., Herman, A. I., Kranzler, H. R., Anton, R. F., Zhao, H., Zheng, W. and Gelernter, J. (2013), Array-Based Profiling of DNA Methylation Changes Associated with Alcohol Dependence. Alcoholism: Clinical and Experimental Research, 37: E108–E115. doi: 10.1111/j.1530-0277.2012.01928.x

Author Information

  1. 1

    Department of Psychiatry , Yale University School of Medicine, New Haven, Connecticut

  2. 2

    VA Connecticut Healthcare System , West Haven, Connecticut

  3. 3

    Department of Psychiatry , University of Pennsylvania Perelman School of Medicine and VISN4 MIRECC, Philadelphia VAMC, Philadelphia, Pennsylvania

  4. 4

    Department of Psychiatry and Behavioral Sciences , Medical University of South Carolina, Charleston, South Carolina

  5. 5

    Department of Genetics , Yale University School of Medicine, New Haven, Connecticut

  6. 6

    Division of Biostatistics , Yale University School of Public Health, New Haven, Connecticut

  7. 7

    Department of Molecular Biophysics & Biochemistry , Yale University School of Medicine, New Haven, Connecticut

  8. 8

    Department of Neurobiology , Yale University School of Medicine, New Haven, Connecticut

*Reprint requests: Huiping Zhang, PhD, Department of Psychiatry, Yale University School of Medicine, VA Medical Center/116A2, 950 Campbell Avenue, West Haven, CT 06516; Tel.: 203-932-5711 ext. 5245; Fax: 203-937-4741; E-mail: huiping.zhang@yale.edu

Publication History

  1. Issue published online: 15 JAN 2013
  2. Article first published online: 24 AUG 2012
  3. Manuscript Accepted: 5 JUN 2012
  4. Manuscript Received: 26 JAN 2012

Funded by

  • National Institute of Health (NIH). Grant Numbers: K99/R00 DA022891, R01 DA12690, R01 AA11330, R01 DA12849, R01 AA017535, R01 DA018432, P50 AA027844, R01 DA011717, K05 AA017435
  • VA CT MIRECC Center
  • Alcoholic Beverage Medical Research Foundation (ABMRF)

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FilenameFormatSizeDescription
acer1928-sup-0001-FigS1-S2-TableS1-S3.pdfapplication/PDF1608KFig. S1. Illumina GoldenGate methylation array assay reproducibility. Fig. S2. CpG sites in the promoter (1,000 bp) and exon 1 (318 bp) of the human serotonin receptor 3A gene (HTR3A). Table S1. Association of Alcohol Dependence and Methylation Changes at 384 CpGs in 82 Candidate Genes (Set I Sample) Table S2. DNA Methylation Differences Between Cases and Controls in Specific Genes (p-Values were Adjusted by Covariates)

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View Full Article with Supporting Information (HTML) Get PDF (206K)