Water resource management is a critical component of eco-industrial parks. This article proposes a methodology, termed the water resource management model for industrial parks, that integrates a water input-output table with water pinch technology. A case study of the Yixing Economic Development Zone (YEDZ) in China illustrates the methodology. Each sector's water utilization and direct and indirect intersectoral interactions of water and water pollutants in 2007 and 2015 are accounted for. It is proposed that water metabolism in 2015 could achieve certain objectives of water resource management in the YEDZ. In addition, future policies are proposed. The YEDZ needs to focus on improving various technologies regarding the manufacture of textiles, the manufacture of raw chemical materials and chemical products, and the production and supply of electric and heat power—which will promote the utilization of water cascading among sectors and encourage the reuse of treated water from wastewater treatment plants. Last, future work for water resource management is proposed.